Near Infrared Microbial Elimination Laser Systems (Nimels) for Use with Medical Devices
First Claim
1. A method of reducing the level of a biological contaminant in a target site without an intolerable adverse effect on a biological moiety, comprising the step of irradiating the target site with an optical radiation having a wavelength from about 905 nm to about 945 nm at a NIMELS dosimetry.
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Accused Products
Abstract
Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e.g., loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850 nm-900 nm and/or 905 nm-945 nm at suitable NIMELS dosimetries.
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Citations
64 Claims
- 1. A method of reducing the level of a biological contaminant in a target site without an intolerable adverse effect on a biological moiety, comprising the step of irradiating the target site with an optical radiation having a wavelength from about 905 nm to about 945 nm at a NIMELS dosimetry.
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2. A method of reducing the level of a biological contaminant in a target site without an intolerable adverse effect on a biological moiety, comprising the step of irradiating the target site with an optical radiation having from about 925 nm to about 935 nm at a NIMELS dosimetry.
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3. A method of reducing the level of a biological contaminant in a target site without an adverse effect on a biological moiety, comprising the steps of:
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(a) irradiating the target site with an optical radiation having a wavelength from about 850 nm to 900 nm at a NIMELS dosimetry; and (b) irradiating the target site with a second optical radiation having a wavelength 905 nm to about 950 nm. - View Dependent Claims (11, 12, 13)
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4. A method of reducing the level of a biological contaminant in a target site without an adverse effect on a biological moiety, comprising the steps of:
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(a) irradiating the target site with an optical radiation having a wavelength from about 865 nm to 875 nm at a NIMELS dosimetry; and (b) irradiating the target site with a second optical radiation having a wavelength 925 nm to about 935 nm.
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28. A therapeutic system comprising:
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an optical radiation generation device configured and arranged to generate optical radiation substantially in a first wavelength range from about 850 nm to about 900 nm or a second optical radiation range having a wavelength from about 905 nm to about 950 nm, or both wavelength ranges; a delivery assembly for causing the optical radiation to be transmitted through an application region; and a controller operatively connected to the optical radiation generation device for controlling dosage of the radiation transmitted through the application region at a NIMELS dosimetry, whereby the time integral of the power density of the transmitted radiation per unit area is below a predetermined threshold of a NIMELS dosimetry. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64)
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Specification