Bio-Film Resistant Surfaces
First Claim
1. A composition for preparing a bio-film resistant surface comprising a biguanide, an alkanediol, and a solvent, where the biguanide is present at between about 0.1 and 5 percent (weight/volume), the alkanediol is present at between about 0.5 and 5 percent (volume/volume), and the solvent is selected from the group consisting of an alcohol, tetrahydrofuran, and mixtures thereof.
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Accused Products
Abstract
The present invention relates to methods and compositions for rendering a surface resistant to bio-film formation by a combination of an alkanediol and an antimicrobial agent (and, optionally, an organic hydroxy acid). The invention provides for compositions which may be used to render surfaces bio-film resistant, articles having bio-film resistant surfaces, and methods for their preparation. The present invention may be advantageously applied to medical articles as well as articles used in non-medical contexts, such as child care or food preparation.
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Citations
57 Claims
- 1. A composition for preparing a bio-film resistant surface comprising a biguanide, an alkanediol, and a solvent, where the biguanide is present at between about 0.1 and 5 percent (weight/volume), the alkanediol is present at between about 0.5 and 5 percent (volume/volume), and the solvent is selected from the group consisting of an alcohol, tetrahydrofuran, and mixtures thereof.
- 25. A method of producing a bio-film resistant surface, comprising exposing the surface to a composition for preparing a bio-film resistant surface comprising a biguanide, an alkanediol, and a solvent, where the biguanide is present at between about 0.1 and 5 percent (weight/volume), the alkanediol is present at between about 0.5 and 5 percent (volume/volume), and the solvent is selected from the group consisting of an alcohol, tetrahydrofuran, and mixtures thereof.
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41. A method of rendering a surface of an article resistant to bio-film formation, comprising:
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(i) applying a first solution to the surface, said first solution comprising an antimicrobial agent, other than a biguanide, at a concentration of between about 0.05 and 3 percent (w/v), and optionally further comprising a hydroxy acid at a concentration between about 0.5 and 3 percent (v/v), in a solvent selected from the group consisting of an alcohol (e.g. methanol, ethanol, isopropanol, and mixtures thereof), tetrahydrofuran and mixtures thereof; (ii) allowing the first solution to dry; (iii) applying a second solution to the surface, said second solution comprising a biguanide at a concentration between about 0.1 and 5 percent (weight/volume), alkanediol at a concentration between about 0.5 and 5 percent (volume/volume), polymer at a concentration between about 1 and 20 percent (weight) volume, a solvent selected from the group consisting of an alcohol (e.g. methanol, ethanol, isopropanol, and mixtures thereof), tetrahydrofuran and mixtures thereof; and
optionally hydroxy acid in an amount of between about 0.5 and 3 percent (volume/volume). - View Dependent Claims (51)
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42. An article having at least one surface comprising, as active agents, a biguanide at between about 250 and 5000 μ
- g/cm2 of surface and an alkanediol at between about 200 and 1500 μ
g/cm2 of surface, and optionally a hydroxy acid at between about 100 and 800 μ
g/cm2 of surface, and/or optionally a silver compound at between about 0-200 μ
g/cm2 of surface.
- g/cm2 of surface and an alkanediol at between about 200 and 1500 μ
Specification