Method of depositing reagent material in a test sensor
First Claim
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1. A method of depositing reagent on an electrochemical test sensor, the test sensor adapted to determine information relating to an analyte, the method comprising the acts of:
- providing a base;
forming an electrode pattern on the base; and
depositing the reagent on at least the electrode pattern using a reagent-dispensing system, the reagent-dispensing system applying mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern.
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Abstract
A method of depositing reagent on an electrochemical test sensor adapted to determine information relating to an analyte includes providing a base and forming an electrode pattern on the base. The method further includes depositing the reagent on at least the electrode pattern using a reagent-dispensing system. The reagent-dispensing system applies mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern.
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Citations
30 Claims
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1. A method of depositing reagent on an electrochemical test sensor, the test sensor adapted to determine information relating to an analyte, the method comprising the acts of:
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providing a base; forming an electrode pattern on the base; and depositing the reagent on at least the electrode pattern using a reagent-dispensing system, the reagent-dispensing system applying mechanical force to the reagent in the reagent-dispensing system to assist in providing a wet reagent droplet on at least the electrode pattern.
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2. A method of forming an electrochemical test sensor, the test sensor being adapted to determine information relating to an analyte, the method comprising the acts of. providing a base;
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forming an electrode pattern on the base; providing a reagent-dispensing system for depositing reagent on at least the electrode pattern, the reagent-dispensing system including a compression member, a piston-needle assembly, an air chamber, a fluid chamber, a nozzle, and a body, the compression member having a compression-adjustment mechanism for adjusting the amount of compression, the piston-needle assembly having a closed position and an open position; supplying the reagent into the fluid chamber, the fluid chamber having a fluid input and a fluid output, the fluid output having an open position and a closed position corresponding to the open and closed positions of the piston-needle assembly; supplying pressurized air to the air chamber to cause the piston-needle assembly to compress the compression member, the piston-needle assembly being in the open position, the fluid output being in the open position; and releasing the supplied pressurized air from the air chamber to allow the compression member to force the piston-needle assembly into the closed position, the piston-needle assembly mechanically forcing a portion of the reagent in the fluid chamber out of the nozzle, the portion of the reagent being deposited on at least the electrode pattern as a wet reagent droplet. - View Dependent Claims (3, 4, 5, 6, 7)
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8. A method of forming an electrochemical test sensor, the test sensor being adapted to determine information relating to an analyte, the method comprising the acts of:
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providing a base; forming an electrode pattern on the base; providing a reagent-dispensing system for depositing reagent on at least the electrode pattern, the reagent-dispensing system including a solenoid control valve, a plunger, a compression member, and a nozzle, the nozzle having an output diameter, the solenoid control valve having an open position and a closed position; supplying pressurized reagent; and opening the control valve of the reagent-dispensing system to cause the pressurized reagent to be dispensed through the nozzle and deposited on at least the electrode pattern as a wet reagent droplet. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. A method of forming an optical test sensor, the optical test sensor being adapted to determine information relating to an analyte, the method comprising the acts of:
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providing a base; providing a reagent-dispensing system for depositing reagent on the base, the reagent-dispensing system including a solenoid control valve, a plunger, a compression member, and a nozzle, the nozzle having an output diameter, the solenoid control valve having an open and a closed position; supplying pressurized reagent; opening the control valve of the reagent-dispensing system to cause the supplied pressurized reagent to be dispensed through the nozzle and deposited on the base as a wet reagent droplet; drying the wet reagent droplet to form a dry reagent layer; providing a lid; and attaching the lid to the base to assist in forming a channel in the test sensor, the channel assisting in allowing a fluid sample to contact the dry reagent layer located on the base.
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- 17. An electrochemical test sensor comprising a base, a lid, a plurality of electrodes and a dried reagent, the dried reagent including an enzyme, a mediator, and a sufficient amount of a multivalent salt such that dried reagent has a uniformity in which the ratio of the thinnest point to the thickest point is greater than about 0.2.
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20. A method of forming an electrochemical test sensor, the method comprising:
- providing a base and a lid,
forming a plurality of electrodes on at least one of the base and the lid; placing reagent solution so as to be in contact with at least one of the electrodes, the reagent solution including an enzyme, a mediator, and a multivalent salt, the multivalent salt having a concentration greater than 40 mM in the reagent solution; and drying the reagent solution after placement thereof. - View Dependent Claims (21, 22, 23, 24, 25)
- providing a base and a lid,
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26. A method of forming an electrochemical test sensor, the method comprising:
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providing a base and a lid, forming a plurality of electrodes on at least one of the base and the lid; placing a reagent solution so as to be in contact with at least one of the electrodes, the reagent solution including an enzyme, a mediator, and an electrolyte, the electrolyte including at least 0.1 wt. % of the reagent solution; and drying the reagent solution after placement thereof. - View Dependent Claims (27, 28, 29, 30)
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Specification