Brain stimulation models, systems, devices, and methods
First Claim
1. A method comprising:
- obtaining volumetric imaging data representing an anatomical volume of a brain of a patient;
transforming at least a portion of the volumetric imaging data to brain atlas data;
creating a patient-specific brain atlas using an inverse of the transformation to map the brain atlas data onto the volumetric imaging data; and
calculating a volume of influence using the patient-specific brain atlas, wherein the volume of influence includes a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.
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Abstract
This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.
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Citations
26 Claims
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1. A method comprising:
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obtaining volumetric imaging data representing an anatomical volume of a brain of a patient; transforming at least a portion of the volumetric imaging data to brain atlas data; creating a patient-specific brain atlas using an inverse of the transformation to map the brain atlas data onto the volumetric imaging data; and calculating a volume of influence using the patient-specific brain atlas, wherein the volume of influence includes a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system comprising:
a processor including an input configured to receive volumetric imaging data representing an anatomical volume of a brain of a patient, wherein the processor is configured to; transform at least a portion of the volumetric imaging data to brain atlas data; create a patient-specific brain atlas using an inverse of the transformation to map the brain atlas data onto the volumetric imaging data; and calculate a volume of influence using the patient-specific brain atlas, wherein the volume of influence includes a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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20. A method comprising:
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obtaining volumetric imaging data representing an anatomical volume of a brain of a patient; defining a set of landmarks on the volumetric imaging data; defining the set of landmarks on brain atlas data; transforming the brain atlas data to the volumetric imaging data using the set of landmarks; and calculating a volume of influence using the transformed brain atlas data, wherein the volume of influence comprises a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location. - View Dependent Claims (21, 22, 23)
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24. A system comprising:
a processor including an input configured to receive volumetric imaging data representing an anatomical volume of a brain of a patient, wherein the processor is configured to; transform brain atlas data to the volumetric imaging data using a set of landmarks defined on the volumetric imaging data and on the brain atlas data; and calculate a volume of influence using the transformed brain atlas data, wherein the volume of influence comprises a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location. - View Dependent Claims (25, 26)
Specification