METHODS FOR FORMING BIODEGRADABLE NANOCOMPONENTS WITH CONTROLLED SHAPES AND SIZES VIA ELECTRIFIED JETTING
First Claim
1. A method of making a multiphasic nano-component comprising:
- forming a plurality of nano-components having a high shape selectivity for a shape selected from the group consisting of;
discs, rods, spheres, toroids, fibers, and combinations thereof, by jetting two or more liquid streams together and passing them through an electric field generated by electrodes sufficient to form a cone jet that forms said plurality of nano-components, each respectively having a first phase and at least one additional phase distinct from said first phase, wherein at least one of said phases comprises a polyester polymer, wherein said forming includes controlling one or more of;
concentration of said polymer in said liquid streams, flow rate of liquid streams, humidity, temperature, design of said electrodes, and configuration of said electrodes during said jetting.
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Abstract
Methods of forming a plurality multiphasic nano-components (MPNs) having at least two phases, with high selectivity for at least one of shape, size, or phase orientation in the nano-component are provided. The methods provide high yields of substantially similar nano-components by controlling one or more of: polymer concentration, liquid stream composition, liquid stream conductivity, flow rate, humidity, temperature, pressure, electrode design and/or configuration during an electrified jetting process. Such methods of making MPNs form shapes including disks, rods, spheres, rectangles, polygons, toroids, cones, pyramids, cylinders, fibers, and combinations thereof. Such MPNs can be used in various applications, including for medical diagnostics or with pharmaceutical, personal care, oral care, and/or nutritional compositions.
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Citations
22 Claims
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1. A method of making a multiphasic nano-component comprising:
forming a plurality of nano-components having a high shape selectivity for a shape selected from the group consisting of;
discs, rods, spheres, toroids, fibers, and combinations thereof, by jetting two or more liquid streams together and passing them through an electric field generated by electrodes sufficient to form a cone jet that forms said plurality of nano-components, each respectively having a first phase and at least one additional phase distinct from said first phase, wherein at least one of said phases comprises a polyester polymer, wherein said forming includes controlling one or more of;
concentration of said polymer in said liquid streams, flow rate of liquid streams, humidity, temperature, design of said electrodes, and configuration of said electrodes during said jetting.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of making a multiphasic nano-component comprising:
forming a plurality of nano-components by jetting two or more liquid streams together and passing them through an electric field generated by electrodes sufficient to form a cone jet, each respective nano-component having a first phase and at least one additional phase distinct from said first phase, wherein at least one of said phases comprises a polymer and said forming of said plurality of nano-components includes controlling one or more of;
concentration of said polymer in said liquid streams, flow rate of said liquid streams, humidity, temperature, design of said electrodes, and configuration of said electrodes during said jetting to form at least about 50% of the plurality of nano-components having substantially the same shape, size, and/or orientation of said first phase or said at least one additional phase.- View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A method of making a multiphasic nano-component comprising:
forming a plurality of nano-components by jetting two or more liquid streams together and passing them through an electric field generated by electrodes sufficient to form a cone jet, each respective nano-component having a first phase and at least one additional phase distinct from said first phase, wherein at least one of said phases comprises a polymer selected from the group consisting of polylactides, polyglycolides, co-polymers, derivatives, and combinations thereof;
wherein said forming of said plurality of nano-components includes controlling one or more of;
concentration of said polymer in said liquid streams, flow rate of said liquid streams, humidity, temperature, design of said electrodes, and configuration of said electrodes during said jetting to form at least about 70% of the plurality of nano-components having substantially the same shape.
Specification