ANALYTE SENSORS COMPRISING BLENDED MEMBRANE COMPOSITIONS AND METHODS FOR MAKING AND USING THEM
First Claim
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1. An amperometric analyte sensor apparatus comprising:
- a base layer;
a conductive layer disposed on the base layer and comprising a working electrode;
an analyte sensing layer disposed on the conductive layer; and
an analyte modulating layer disposed on the analyte sensing layer, wherein;
the analyte modulating layer comprises a blended mixture of;
a linear polyurethane/polyurea polymer, anda branched acrylate polymer; and
the linear polyurethane/polyurea polymer and the branched acrylate polymer are blended at a ratio of between 1;
1 and 1;
20 by weight %.
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Abstract
Embodiments of the invention provide analyte sensors having elements designed to modulate their chemical reactions as well as methods for making and using such sensors. In certain embodiments of the invention, the sensor includes an analyte modulating membrane that comprises a blended mixture of a linear polyurethane/polyurea polymer, and a branched acrylate polymer.
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Citations
25 Claims
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1. An amperometric analyte sensor apparatus comprising:
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a base layer; a conductive layer disposed on the base layer and comprising a working electrode; an analyte sensing layer disposed on the conductive layer; and an analyte modulating layer disposed on the analyte sensing layer, wherein; the analyte modulating layer comprises a blended mixture of; a linear polyurethane/polyurea polymer, and a branched acrylate polymer; and the linear polyurethane/polyurea polymer and the branched acrylate polymer are blended at a ratio of between 1;
1 and 1;
20 by weight %. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of making an analyte sensor apparatus for implantation within a mammal comprising the steps of:
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providing a base layer; forming a conductive layer on the base layer, wherein the conductive layer includes a working electrode; forming an analyte sensing layer on the conductive layer, wherein the analyte sensing layer includes an oxidoreductase; forming an analyte modulating layer on the analyte sensing layer, wherein; the analyte modulating layer comprises a blended mixture of; a linear polyurethane/polyurea polymer, and a branched acrylate polymer; and the linear polyurethane/polyurea polymer and the branched acrylate polymer are blended at a ratio of between 1;
1 and 1;
20 by weight %; andforming a cover layer on the analyte modulating layer. - View Dependent Claims (16, 17, 18, 19)
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20. A composition of matter comprising a blend of:
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(1) a first polymer formed from a mixture comprising; (a) a diisocyanate compound; (b) at least one hydrophilic diol or hydrophilic diamine compound; and (c) a siloxane compound; and (2) a second polymer formed from a mixture comprising; (a) 5-45 weight % of a 2-(dimethylamino)ethyl methacrylate compound; (b) 15-55 weight % of a methyl methacrylate compound; (c) 15-55 weight % of a polydimethyl siloxane monomethacryloxypropyl compound; and (d) 5-35 weight % of a poly(ethylene oxide)methyl ether methacrylate compound; wherein the first polymer and the second polymer are blended together at a ratio between 1;
1 and 1;
20 weight %. - View Dependent Claims (22, 23, 24, 25)
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21. The composition of 20, wherein the first polymer further comprises a compound that functions as a chain extender.
Specification