SURFACE ENHANCED SPECTROSCOPY-ACTIVE COMPOSITE NANOPARTICLES

• US 20110172523A1
• Filed: 10/03/2008
• Published: 07/14/2011
• Est. Priority Date: 10/06/1999
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Oxonica, Inc.
• Inventors: Natan, Michael J., Doering, William E.
• Granted Patent: US 8,918,161 B2
• Time in Patent Office: Days
• US Class Current: 600/431
• CPC Class Codes: B22F 1/054 Nanosized particles
• CPC Class Codes: B22F 1/0547 Nanofibres or nanotubes
• CPC Class Codes: B22F 1/0553 Complex form nanoparticles, e.g. prism, pyramid, octahedron
• CPC Class Codes: B22F 1/056 Submicron particles having a size above 100 nm up to 300 nm
• CPC Class Codes: B22F 1/102 Metallic powder coated with organic material
• CPC Class Codes: B22F 1/17 Metallic particles coated with metal
• CPC Class Codes: B22F 2998/00 Supplementary information concerning processes or compositions relating to powder metallurgy
• CPC Class Codes: B22F 9/14 using electric discharge
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C25D 1/006 Nanostructures, e.g. using aluminium anodic oxidation templates [AAO]
• CPC Class Codes: C25D 1/04 Wires; Strips; Foils
• CPC Class Codes: G01N 21/658 enhancement Raman, e.g. surface plasmons
• CPC Class Codes: G01N 2201/06113 Coherent sources; lasers
• CPC Class Codes: G01N 2201/068 Optics, miscellaneous
• CPC Class Codes: G01N 33/54346 Nanoparticles
• CPC Class Codes: Y10T 436/13 Tracers or tags

Abstract

Submicron-sized particles or labels that can be covalently or non-covalently affixed to entities of interest for the purpose of quantification, location, identification, tracking, and diagnosis, are described.

Claims

1. A method comprising,

a) administering a SACN nanoparticle imaging agent to a patient,

b) scanning the patient using a system that can perform spectral imaging;

and

c) generating a spectrum or image of an internal region of the patient.

2. The method of claim 1, wherein said system is selected from the group consisting of a spot scanning confocal microscope, a line scanning system, an Optical Coherence tomographic system, a system that detects only over a single wavelength band, a fluorescence imaging system comprising an excitation light source and filtered image detection.

3. The method of claim 1, wherein the region of a patient is selected from the group consisting of the whole patient, the vasculature, heart, liver, and spleen, the gastrointestinal region.

4. The method of claim 1, wherein the system that can perform spectral imaging is a portable system.

7. The method of claim 1, wherein said SACN is non-covalently associated with an imaging probe, wherein said administering comprises introducing the imaging probe, and wherein said SACNs disassociate into the tissue or a bodily fluid.

5. A method, comprising:

a) introducing a plurality of SACNs targeted to a molecule involved in an abnormal pathology into a patient with the abnormal pathology, wherein the SACNs become associated to a molecule associated with the abnormal pathology; and

b) obtaining an imaging of the associated SACNs,

whereby an abnormal pathology may be diagnosed.

6. The method of claim 5, wherein said the location of the abnormal pathology comprises the gastro-intestinal tract, heart, lung, liver cervix, breast, and colon.

8. A method for labeling an animal with a SACN, comprising introducing a SACN into an animal, wherein said introducing is selected from the group consisting of subcutaneous implantation, intravenous introduction.

9. The method of claim 8, further comprising detecting the SACN or labeled animal.