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NUMBER CODING FOR IDENTIFICATION OF SUBTYPES OF CODED TYPES OF SOLID PHASE CARRIERS

  • US 20110184655A1
  • Filed: 03/24/2011
  • Published: 07/28/2011
  • Est. Priority Date: 09/18/2003
  • Status: Active Grant
First Claim
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1. A method of expanding the set of distinguishable codes for encoding particles in a bioassay of a sample, where analytes are distinguished using encoded particles displaying different ligands, where ligands which bind to different analytes can be distinguished through the codes, comprising:

  • forming groups, each group made up of different numbers of particles having the same code, where members of each group display up to four different ligands, and wherein the number of particles in each group displaying the same ligand has a unique decomposition into one or more summands, such that no partial sum of one or more summands can be obtained in any other way of combining summands, and no summand is itself the sum of two or more of the other summands;

    reacting the sample with the particles;

    determining for each group of particles, the number of particles generating a positive assay signal;

    comparing for each group of particles, said number with the number of particles displaying each said different ligand; and

    determining for each group of particles, which analytes which bind to the ligands attached to the particles in a group, are present in the sample.

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