DEGRADATION RESISTANT IMPLANTABLE MATERIALS AND METHODS
First Claim
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1. A method of making a material suitable for implantation in a mammal, the method comprising:
- providing a base member including a porous surface defined by interconnected pores;
contacting the base member with a silicone-based fluid material in a manner to cause the fluid material to enter the pores;
removing excess fluid material from the base member to obtain a coating of the fluid material on the porous surface; and
allowing the coating to set to form a silicone-based structure suitable for implantation in a mammal, the silicone-based structure including a porous surface substantially identically conforming to the porous surface of the base member.
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Abstract
Methods are provided for making materials suitable for implantation in a mammal. The methods include the steps of providing a base material having a desirable surface topography, such as a polyurethane foam, contacting the base member with a silicone-based fluid material to form a coating, and allowing the coating to set to form a silicone-based structure suitable for implantation in a mammal. The base material may be removed from the coating.
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Citations
21 Claims
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1. A method of making a material suitable for implantation in a mammal, the method comprising:
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providing a base member including a porous surface defined by interconnected pores; contacting the base member with a silicone-based fluid material in a manner to cause the fluid material to enter the pores; removing excess fluid material from the base member to obtain a coating of the fluid material on the porous surface; and allowing the coating to set to form a silicone-based structure suitable for implantation in a mammal, the silicone-based structure including a porous surface substantially identically conforming to the porous surface of the base member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 21)
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9. A method of making a material suitable for implantation in a mammal, the method comprising:
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providing a base member comprising a biodegradable foam and including a porous surface defined by interconnected pores; contacting the base member with a fluid precursor of a substantially non-biodegradable polymeric material in a manner to cause the fluid precursor to enter the pores; removing excess fluid precursor from the base member to obtain a coating of the fluid precursor on the porous surface; and allowing the coating to set to form a substantially non-biodegradable polymeric structure suitable for implantation in a mammal, the substantially non-biodegradable polymeric structure including a porous surface substantially identically conforming to the porous surface of the base member. - View Dependent Claims (10, 11, 12)
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13. A method of making a material suitable for implantation in a mammal, the method comprising:
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providing a base member made of a biodegradable foam and including a porous surface defined by interconnected pores; contacting the base member with a fluorinated polyolefin material in a manner to cause the fluorinated polyolefin material to enter the pores; allowing the fluorinated polyolefin material to set to form a fluorinated polyolefin coating on the base member; contacting the fluorinated polyolefin coating with a silicone-based fluid material; allowing the silicone-based fluid material to set to form a layered polymeric structure suitable for implantation in a mammal, the layered polymeric structure including a porous surface substantially identically conforming to the porous surface of the base member.
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14. A method of making a material suitable for implantation in a mammal, the method comprising:
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providing a polymeric base member having a surface defined by a geometry including interconnected pores; forming a first coating on the surface of the base member material, the first coating being selected from the group of materials consisting of polystyrene, polyethylene-co-vinyl acetate, and poly(styrene-co-butadiene-co-styrene); removing the polymeric base member by contacting the base material with a material that will cause the base member to be removed from the first coating without causing degradation of the coating; applying a silicone-based fluid material to the first coating having the polymeric base member removed therefrom; curing the silicone-based fluid material to form a silicone-based coating on the first coating; and removing the first coating from the silicone coating. - View Dependent Claims (15)
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16. A method of making a material suitable for implantation in a mammal, the method comprising:
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providing a base material comprising polyurethane foam having a surface defined by interconnected pores; contacting the base material with a fluorinated polymeric material in a manner to cause the fluorinated polymeric material to enter the pores and form a fluorinated polymeric coating on the base material thereby forming a biocompatible, substantially non-biodegradable composite material. - View Dependent Claims (17, 18, 19, 20)
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Specification