CHEMICAL/BIOLOGICAL SENSOR EMPLOYING SCATTERED CHROMATIC COMPONENTS IN NANO-PATTERNED APERIODIC SURFACES
First Claim
1. Apparatus, comprising:
- a substrate having a surface with a deterministic, aperiodic nano-scale pattern;
a source of light directed at the surface of the substrate;
a detector operative to receive a pattern of light scattered off the surface of the substrate and to convert the received pattern of light to a corresponding color image, the color image having a colorimetric spatial distribution pattern; and
image processing circuitry operative to perform pattern recognition on the colorimetric spatial distribution pattern to detect the presence of an analyte on the surface of the substrate.
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Accused Products
Abstract
A label-free multiplexed sensing platform is based on light interaction with aperiodic photonic structures with an advantage of a broadband operation. Multiple-scattering-induced “fingerprinting” colorimetric signatures can be used as a transduction mechanism. Aperiodic sensing platforms can operate in the infrared to provide an overlap with spectral fingerprints of biological molecules. Miniaturized optical biosensors may be based on engineered colorimetric scattering signatures (structural color), sharp spectral features, non-uniform angular distributions of scattered light, and broadband manipulation of the local density of states in nano-textured scattering surfaces with deterministic aperiodic order. The biosensors can be fabricated in semiconductor, metal, low- and high-index dielectric platforms using standard nanofabrication techniques such as electron-beam lithography, ion-beam milling, etc, and can be replicated over large areas by standard nano-imprint lithography.
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Citations
26 Claims
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1. Apparatus, comprising:
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a substrate having a surface with a deterministic, aperiodic nano-scale pattern; a source of light directed at the surface of the substrate; a detector operative to receive a pattern of light scattered off the surface of the substrate and to convert the received pattern of light to a corresponding color image, the color image having a colorimetric spatial distribution pattern; and image processing circuitry operative to perform pattern recognition on the colorimetric spatial distribution pattern to detect the presence of an analyte on the surface of the substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method, comprising:
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directing light at a surface of a substrate, the surface having a deterministic, aperiodic nano-scale pattern; detecting a pattern of light scattered off the surface of the substrate and converting the received pattern of light to a corresponding color image, the color image having a colorimetric spatial distribution pattern; and performing pattern recognition on the colorimetric spatial distribution pattern to detect the presence of an analyte on the surface of the substrate. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification