SILICONE BASED MEMBRANES FOR USE IN IMPLANTABLE GLUCOSE SENSORS
First Claim
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1. An implantable continuous analyte sensor, comprising:
- a working electrode; and
a membrane disposed over at least a portion of the working electrode, the membrane comprising a blend, the blend comprising a silicone polymer and a hydrophilic polymer.
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Abstract
Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
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Citations
25 Claims
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1. An implantable continuous analyte sensor, comprising:
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a working electrode; and a membrane disposed over at least a portion of the working electrode, the membrane comprising a blend, the blend comprising a silicone polymer and a hydrophilic polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An implantable continuous analyte sensor, comprising:
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a working electrode; and a membrane disposed over the working electrode, the membrane comprising; a first domain comprising a blend of a silicone polymer and a hydrophilic polymer; a second domain comprising an enzyme configured to react with an analyte; and a third domain comprising ionic components configured to reduce permeability of the third domain to an interfering species. - View Dependent Claims (16, 17)
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18. An implantable continuous analyte sensor, comprising:
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a working electrode; and a membrane system disposed over at least a portion of the working electrode, the membrane system comprising a first domain and a second domain, the first domain and the second domain each comprising a blend comprising a silicone polymer and a hydrophilic polymer, the first domain having a blend ratio of silicone polymer to hydrophilic polymer that is different than a blend ratio of silicone polymer to hydrophilic polymer of the second domain. - View Dependent Claims (19, 20)
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21. An implantable continuous analyte sensor, comprising:
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a working electrode; and a membrane disposed over the working electrode, the membrane comprising; a first domain configured to selectively reduce a permeability of a first interfering species therethrough; a second domain comprising an enzyme configured to react with an analyte; and a third domain configured to selectively reduce a permeability of a second interfering species therethrough. - View Dependent Claims (22, 23, 24, 25)
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Specification