METHODS AND SYSTEMS FOR DOSING A MEDICAMENT

• US 20120101451A1
• Filed: 10/22/2010
• Published: 04/26/2012
• Est. Priority Date: 10/22/2010
• Status: Active Grant

• Current Assignee: CeQur SA
• Original Assignee: CeQur SA
• Inventors: Boit, Christopher S., Gravesen, Peter, Arndt, Heiko, Peatfield, Gregory H., McDermott, Patrick F.
• Granted Patent: US 9,211,378 B2
• Time in Patent Office: Days
• US Class Current: 604/224
• CPC Class Codes: A61M 2005/3123 having air entrapping or venting means, e.g. purging channels in pistons
• CPC Class Codes: A61M 2039/224 of the slide-valve type
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 39/223 Multiway valves
• CPC Class Codes: A61M 5/141 with capillaries for restricting fluid flow
• CPC Class Codes: A61M 5/1413 Modular systems comprising interconnecting elements
• CPC Class Codes: A61M 5/1424 Manually operated pumps
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/148 flexible, e.g. independent bagsA61M5/155 takes precedence
• CPC Class Codes: A61M 5/16809 by repeated filling and emptying of an intermediate volume pressure infusion using positive displacement pumps A61M5/142
• CPC Class Codes: A61M 5/3153 by single stroke limiting means
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence

Abstract

A manually actuated pump, such as a bolus delivery circuit of an insulin pump, combines a direct drive piston system with a lost motion valve system, to deliver reliably a full bolus dose, while precluding partial dosing or inadvertent overdosing conditions. The pump may also include a signaling device to indicate when a full bolus dose is delivered.

Claims

1. A method of dosing a medicament using a mechanical pump system comprising an actuation element, a direct drive piston system including a piston, and a lost motion valve system, the method comprising the steps of:

moving the actuation element from a rest position to a fill end position to fill incrementally a piston chamber of the piston system with medicament from a reservoir;

moving the actuation element an additional distance to a point of no return to move a valve of the valve system from a fill position to a dosing position; and

moving the actuation element past the point of no return to force a full dose of medicament out of the piston chamber to a dosing conduit.

2. The method of claim 1, wherein moving the actuation element from the rest position to the fill end position retracts the piston relative to the piston chamber.

3. The method of claim 1, wherein the direct drive piston system comprises at least one of a rack and gear system and a cam and follower system.

4. The method of claim 3, wherein the direct drive piston system comprises both the rack and gear system and the cam and follower system.

5. The method of claim 1, wherein moving the actuation element from the rest position to the fill end position does not move the valve.

6. The method of claim 1, wherein when the actuation element is moved past the point of no return, the piston is decoupled from the actuation element and automatically delivers a full dose of medicament to the dosing conduit.

7. The method of claim 1 further comprising the step of returning the actuation element to the rest position after dosing to reset the mechanical pump system.

8. The method of claim 7, wherein the actuation element is returned to the rest position automatically.

9. The method of claim 7, wherein the actuation element passes through a reengagement position prior to reaching the rest position.

10. The method of claim 9, wherein cycling of the actuation element from past the point of no return to a position intermediate with the reengagement position delivers no additional medicament.

11. -25. (canceled)

26. A mechanical pump system comprising:

an actuation element;

a direct drive piston system comprising;

a piston chamber;

a piston disposed within the piston chamber; and

a direct drive coupled to the actuation element for moving the piston relative to the piston chamber when the actuation element moves from a rest position to a fill end position to fill incrementally the piston chamber with medicament; and

a lost motion valve system comprising;

a valve chamber; and

a valve disposed within the valve chamber, wherein the valve is displaced from a fill position to a dosing position after the actuation element travels beyond the fill end position.

27. The mechanical pump system of claim 26, wherein the actuation element comprises a manually operable button.

28. The mechanical pump system of claim 26, wherein the direct drive comprises at least one of a rack and gear system and a cam and follower system.

29. The mechanical pump system of claim 28, wherein the direct drive comprises both the rack and gear system and the cam and follower system.

30. The mechanical pump system of claim 29, wherein the cam and follower system comprises a cam disk with a track for constraining motion of a piston bar coupled to the piston.

31. The mechanical pump system of claim 30, wherein the track comprises a point corresponding to a point of no return of the actuation element beyond which the piston becomes decoupled from the actuation element.

32. The mechanical pump system of claim 31, wherein the direct drive further comprises a ratchet element mating with the cam disk to decouple the actuation element from the piston.

33. The mechanical pump system of claim 32 further comprising a piston spring for biasing the piston to empty the piston chamber when the piston is decoupled from the actuation element.

34. The mechanical pump system of claim 32, wherein the cam disk comprises a ledge for mating with the ratchet element to recouple the actuation element to the piston at a reengagement position.

35. The mechanical pump system of claim 34, wherein the ratchet element and the cam disk are configured such that cycling of the actuation element from past the point of no return to a position intermediate with the reengagement position fails to deliver medicament through the valve.

36. -52. (canceled)