DETECTING NEUROCHEMICAL OR ELECTRICAL SIGNALS WITHIN BRAIN TISSUE
First Claim
1. A probe comprising a first sensor having the ability to detect a first neurochemical and a second sensor having the ability to detect a second neurochemical, wherein said first and second neurochemicals are selected from the group consisting of dopamine, serotonin, adenosine, adenine mono- or tri-phosphate, norepinephrine, GABA, histamine, acetylcholine, glutamate, aspartate, epinephrine, nitric oxide, glycine, tryptamine, phenylethylamine, tyramine, and octopamine.
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Accused Products
Abstract
This document relates to methods and materials involved in detecting neurochemical signals, electrophysiological signals, ions, or combinations thereof with brain tissue. For example, methods and materials for using probes to detect neurochemical signals (e.g., neurotransmitter concentrations), electrical signals, or combinations thereof during deep brain stimulation are provided.
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Citations
26 Claims
- 1. A probe comprising a first sensor having the ability to detect a first neurochemical and a second sensor having the ability to detect a second neurochemical, wherein said first and second neurochemicals are selected from the group consisting of dopamine, serotonin, adenosine, adenine mono- or tri-phosphate, norepinephrine, GABA, histamine, acetylcholine, glutamate, aspartate, epinephrine, nitric oxide, glycine, tryptamine, phenylethylamine, tyramine, and octopamine.
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11. A probe comprising a first sensor having the ability to detect a first ion and a second sensor having the ability to detect a second ion, wherein said first and second ions are selected from the group consisting of calcium, magnesium, sodium, potassium, protons, iron, copper, chromium, lead, mercury, cobolt, gold, lithium, cesium, barium, zinc, chloride, bicarbonate, phosphate, bromide, iodide, sulfide, oxide, sulfide, and flouride.
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12. A deep brain stimulation system comprising:
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(a) a probe comprising a sensor capable of detecting a neurochemical or an ion and an electrode capable of applying an electrical stimulus to brain tissue, and (b) a processing unit in wireless communication with said probe, wherein said processing unit is capable of receiving information from said probe about the level of said neurochemical and is capable of sending information to said probe about the level or timing of electrical stimulus to deliver to said brain tissue. - View Dependent Claims (13, 14, 15, 16, 17, 18, 26)
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19. A deep brain stimulation system comprising:
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(a) a probe comprising a sensor capable of detecting a neurochemical or ion and an electrode capable of applying an electrical stimulus to brain tissue, and (b) a control unit in communication with said probe, wherein said control unit is capable of receiving information from said probe about the level of said neurochemical and is capable of sending information to said probe about the level or timing of electrical stimulus to deliver to said brain tissue. - View Dependent Claims (20, 21, 22, 23, 24, 25)
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Specification