SYSTEMS, METHODS AND COMPUTER-READABLE MEDIUM FOR DETERMINING DEPTH-RESOLVED PHYSICAL AND/OR OPTICAL PROPERTIES OF SCATTERING MEDIA BY ANALYZING MEASURED DATA OVER A RANGE OF DEPTHS
First Claim
1. A method for determining at least one property of at least one biological structure, comprising:
- (a) obtaining a plurality of signals received at particular depths within the at least one biological structure, wherein at least first one of the signals is obtained from a first depth of the particular depths, and at least second one of the signals is obtained from a second depth of the particular depths, the first and second depths being different from one another;
(b) determining information based on the signals and an assumed property of the at least one biological structure; and
(c) determining at least one calculated property based on the information by excluding at least a portion of the information associated with the signals provided from the particular depths that are closer than a predetermined depth within the at least one biological structure, wherein the calculated property is an attenuation property.
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Abstract
In depth-resolved imaging of scattering media, incident light interacts with tissue in a complex way before the signal reaches the detector: Light interacts with media between the light source and a specific depth, then scatters at that depth and the backscattered light again interacts with media on its way to the detector. The resulting depth-resolved signal therefore likely does not directly represent a physical or optical property of the media at those depths. Exemplary systems, methods and computer-accessible medium can determine physical or optical properties based on such depth-resolved signals. For example, almost all the light can interact with the media, and that the energy of the incident light at a certain depth is likely therefore related to the integral of the scattered light from all deeper locations. Based on the detected signals, the properties of the media can be estimated in an iterative way.
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Citations
27 Claims
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1. A method for determining at least one property of at least one biological structure, comprising:
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(a) obtaining a plurality of signals received at particular depths within the at least one biological structure, wherein at least first one of the signals is obtained from a first depth of the particular depths, and at least second one of the signals is obtained from a second depth of the particular depths, the first and second depths being different from one another; (b) determining information based on the signals and an assumed property of the at least one biological structure; and (c) determining at least one calculated property based on the information by excluding at least a portion of the information associated with the signals provided from the particular depths that are closer than a predetermined depth within the at least one biological structure, wherein the calculated property is an attenuation property. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A system for determining at least one property of at least one biological structure, comprising:
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at least one first arrangement which is configured to obtain a plurality of signals received at particular depths within the at least one biological structure, wherein at least first one of the signals is obtained from a first depth of the particular depths, and at least second one of the signals is obtained from a second depth of the particular depths, the first and second depths being different from one another; and at least one second computing arrangement which is configured to determine; information based on the signals and an assumed property of the at least one biological structure; and at least one calculated property based on the information by excluding at least a portion of the information associated with the signals provided from the particular depths that are closer than a predetermined depth within the at least one biological structure, wherein the at least one calculated property is an attenuation property, - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A non-transitory computer accessible medium which includes software thereon for determining at least one property of at least one biological structure, wherein, when a computing arrangement executes the software, the computing arrangement is configured to perform procedures comprising:
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(a) cause a plurality of signals received at particular depths within the at least one biological structure to be received, wherein at least first one of the signals is obtained from a first depth of the particular depths, and at least second one of the signals is obtained from a second depth of the particular depths, the first and second depths being different from one another; (b) determine information based on the signals and an assumed property of the at least one biological structure; and (c) determine at least one calculated property based on the information by excluding at least a portion of the information associated with the signals provided from the particular depths that are closer than a predetermined depth within the at least one biological structure, wherein the calculated property is an attenuation property.
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Specification