METHOD OF BIOIMAGE DATA PROCESSING FOR REVEALING MORE MEANINGFUL ANATOMIC FEATURES OF DISEASED TISSUES
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Abstract
The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.
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Citations
27 Claims
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1. (canceled)
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2. A method of collecting optical coherence tomography data of an eye, said eye having at least one boundary surface associated therewith, said method comprising;
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acquiring an initial set of image data of the eye using an optical coherence tomography (OCT) device, said OCT device including a light source and optical elements to scan the beam over the eye; identifying a curved boundary surface within the image data; generating a substantially smoothed reference surface from the boundary surface; and acquiring further image data by scanning the eye with the beam, wherein the scanning is guided by the contour of the smoothed reference surface. - View Dependent Claims (3, 4, 5, 6, 7, 8)
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9. A method of displaying image data, said data obtained from imaging an eye using an imaging device, said eye having at least one boundary surface associated therewith, said method comprising:
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identifying a boundary surface within the image data set; generating a substantially smooth reference surface from the boundary surface; identifying a second surface within the 3D image data set; calculating the distance between points on the smooth reference surface and corresponding points on the second surface; generating an image map of the calculated distances; displaying the image map; and simultaneously displaying an additional data set along with the image map. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of analyzing optical coherence tomography data of an eye, said eye having at least one boundary surface associated therewith, said method comprising;
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acquiring an initial set of image data of the eye using an optical coherence tomography (OCT device, said OCT device including a light source, a beam splitter for dividing the light along a sample arm and a reference arm, said sample arm further including optical elements to scan the beam over the eye, said OCT device including a detector for receiving light returned from both the sample and the reference arms and generating signals corresponding to 3D image data based on an axial reflection distribution arising from reflecting features in the eye; identifying a boundary surface within the 3D image data set; generating a substantially smooth reference surface from the boundary surface; analyzing the curvature of the smooth reference surface to provide information on the disease status of the eye. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
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Specification