FLUX LIMITING MEMBRANE FOR INTRAVENOUS AMPEROMETRIC BIOSENSOR
First Claim
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1. A flux limiting membrane for an intravenous amperometric biosensor, comprising:
- an ethylene vinylacetate (EVA) polymer at least partially coating a reagent disposed on an electrode of the biosensor to limit a rate at which a reactant from blood diffuses to the reagent.
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Abstract
A flux limiting layer for an intravenous amperometric biosensor is formed on a substrate to limit a diffusion rate of an analyte from blood to an enzyme electrode. The layer may be formed from ethylene vinylacetate (EVA) dissolved in a solvent such as paraxylene, spray-coated to cover a portion of the electrode, and cured to seal the electrode to the substrate. In a glucose sensor having glucose oxidase disposed on the electrode, thickness and concentration of the EVA layer are optimized to promote a linear output of electrode current as a function of blood glucose concentration.
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Citations
30 Claims
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1. A flux limiting membrane for an intravenous amperometric biosensor, comprising:
an ethylene vinylacetate (EVA) polymer at least partially coating a reagent disposed on an electrode of the biosensor to limit a rate at which a reactant from blood diffuses to the reagent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An intravenous amperometric biosensor, comprising:
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a substrate; an electrode bonded to the substrate; a reagent disposed on the electrode; and an ethylene vinylacetate (EVA) flux limiting membrane at least partially coating the reagent to limit a rate at which a reactant from blood diffuses to the reagent. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. On a biosensor having an enzyme electrode disposed on a substrate, a method for forming a flux limiting membrane on the enzyme electrode, comprising:
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dissolving ethylene vinylacetate (EVA) in a solvent; applying a layer of the dissolved EVA to an area of the substrate that includes at least a portion of the enzyme electrode; and curing the applied layer. - View Dependent Claims (26, 27, 28, 29, 30)
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Specification