ANALYTE SENSOR WITH INCREASED REFERENCE CAPACITY
First Claim
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1. An implantable electrochemical sensor for measuring an analyte concentration in a host, comprising:
- a working electrode configured to measure a concentration of an analyte; and
a silver/silver chloride reference electrode, wherein at least a portion of the silver/silver chloride reference electrode is covered with an enzyme layer, wherein the enzyme layer is configured, in vivo, to generate hydrogen peroxide upon exposure to a substrate, whereby the hydrogen peroxide regenerates silver chloride of the reference electrode such that a reference capacity of the reference electrode is increased.
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Abstract
Systems and methods of use for continuous analyte measurement of a host'"'"'s vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.
49 Citations
27 Claims
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1. An implantable electrochemical sensor for measuring an analyte concentration in a host, comprising:
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a working electrode configured to measure a concentration of an analyte; and a silver/silver chloride reference electrode, wherein at least a portion of the silver/silver chloride reference electrode is covered with an enzyme layer, wherein the enzyme layer is configured, in vivo, to generate hydrogen peroxide upon exposure to a substrate, whereby the hydrogen peroxide regenerates silver chloride of the reference electrode such that a reference capacity of the reference electrode is increased. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. An electrochemical sensor for measuring an analyte concentration in a host, comprising:
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a working electrode configured to measure a concentration of an analyte; and a reference electrode, wherein at least a portion of the reference electrode is covered with an enzyme layer, wherein the enzyme layer is configured, in vivo, to generate a reference electrode regenerating species upon exposure to a substrate, whereby the reference electrode regenerating species regenerates a component of the reference electrode such that a reference capacity of the reference electrode is increased. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. An electrochemical sensor for measuring an analyte concentration in a host, comprising:
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a working electrode configured to measure a concentration of an analyte; and a reference electrode comprising a material that depletes during sensor use, wherein the material is configured to be regenerated during sensor use, and wherein a rate of material depletion during sensor use substantially correlates with a rate of material regeneration during sensor use over a time period. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification