NON-ENZYMATIC GLUCOSE SENSOR

• US 20140061044A1
• Filed: 09/05/2013
• Published: 03/06/2014
• Est. Priority Date: 09/06/2012
• Status: Active Grant

• Current Assignee: Amrita Vishwa Vidyapeetham Deemded University
• Original Assignee: Amrita Vishwa Vidyapeetham Deemded University
• Inventors: THEKKEDATH, SATHEESH BABU G., THIAGARAJAN, RAMACHANDRAN, NAIR, BIPIN G.
• Granted Patent: US 9,606,080 B2
• Time in Patent Office: Days
• US Class Current: 204/403.01
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: G01N 27/30 Electrodes, e.g. test electrodes; Half-cells G01N27/414 takes precedence
• CPC Class Codes: G01N 27/327 Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements
• CPC Class Codes: G01N 27/3275 Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
• CPC Class Codes: G01N 27/3278 involving nanosized elements, e.g. nanogaps or nanoparticles nanopores G01N33/48721; magnetic beads G01N27/745

Abstract

A non-enzymatic glucose sensor and method for fabricating the sensor are disclosed. The glucose sensor contains at least one non-enzymatic electrode configured to catalyze the electro-oxidation of glucose in preference to other bio-molecules. The surface of the electrode comprises CuO nanoparticles. The sensor shows sensitivity and selectivity exceeding enzyme based devices presently in use.

Claims

1. A device for detecting glucose, comprising:

at least one active electrode configured to catalyze the electro-oxidation of glucose in preference to other bio-molecules;

wherein the active electrode consists essentially of CuO nanoparticles, and wherein, the CuO nanoparticles are deposited in alkaline medium comprising NaOH.

2. The device of claim 1, wherein the device is configured to produce response currents in the μ

A range when exposed to glucose concentrations in the mM range.

3. The device of claim 1, wherein the electrode comprises a silver-based body that is coated substantially with conducting carbon ink.

5. The device of claim 1, wherein the size of the nanoparticles ranges from 5 nm to 500 nm.

4. The device of claim 4, wherein the copper oxide nanoparticles comprises spherical, elongated copper oxide nanoparticles, and/or copper oxide nanowires.

6. A method for fabricating a glucose sensor, comprising:

providing an insulating base plate/substrate;

forming one or more disposable silver-based electrodes on the substrate;

coating conducting carbon ink over the electrodes; and

coating CuO nanoparticles over the electrodes, wherein, the CuO nanoparticles are processed in alkaline medium.

7. The method of claim 6, wherein the size of the CuO nanoparticles ranges from 5 nm to 500 nm.

8. The method of claim 6, wherein the CuO nanoparticles are spherical particles prepared by annealing copper hydroxide above 400°

C.

9. The method of claim 6, wherein the CuO nanoparticles are elongated particles prepared by annealing copper hydroxide complex at 400°

C. for three hours.

10. The method of claim 9, wherein the CuO nanoparticles are nanowires prepared by annealing copper hydroxide at around 180°

C.