Compartementalized integrated biochips

• US 20140100141A1
• Filed: 10/04/2013
• Published: 04/10/2014
• Est. Priority Date: 10/10/2012
• Status: Active Application

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Inventors: Wang, Shan X., Bechstein, Daniel Jacob Benjamin
• Granted Patent: US 10,261,073 B2
• Time in Patent Office: Days
• US Class Current: 506/39
• CPC Class Codes: B01L 2200/0689 Sealing
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2200/16 Reagents, handling or storing thereof
• CPC Class Codes: B01L 2300/0636 Integrated biosensor, microarrays
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0883 Serpentine channels
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: G01N 33/5302 Apparatus specially adapted for immunological test procedures

Abstract

An integrated microfluidic biochip is provided that includes a microfluidic device, where the microfluidic device includes hollow structures, where at least one the hollow structure includes an output at a bottom surface of the microfluidic device, and a sensor plate, where the sensor plate comprises a plurality of independent surface sensors, where the microfluidic device is sealably attachable to the sensor plate, where the hollow structure output abuts the surface sensor when the microfluidic device is attached to the sensor plate.

Claims

1. An integrated microfluidic biochip, comprising:

a. a microfluidic device, wherein said microfluidic device comprise hollow structures, wherein at least one said hollow structure comprise a reagent interface at a bottom surface of said microfluidic device; and

b. a sensor plate, wherein said sensor plate comprises a plurality of independent surface sensors, wherein said microfluidic device is sealably attachable to said sensor plate, wherein said hollow reagent interface abuts said surface sensor when said microfluidic device is attached to said sensor plate.

2. The integrated microfluidic biochip of claim 1, wherein said microfluidic device comprises a plurality of microfluidic layers, where said plurality of microfluidic layers is interconnected by hollow vias.

3. The integrated microfluidic biochip of claim 2, wherein said interconnected plurality of layers are capable of sealably interfacing a microfluidic chip, wherein said microfluidic chip comprises dimensions that are larger than dimensions of said sensor plate surface.

4. The integrated microfluidic biochip of claim 3, wherein i) said hollow structures, ii) said surface sensors, iii) said microfluidic chip, i) and ii), i) and iii), ii) and iii), or i) and ii) and iii) are disposed to compartmentalize separate analytes.

5. The integrated microfluidic biochip of claim 2, wherein said microfluidic layers comprises control channels and flow channels, wherein said control channels comprise i) a valve, ii) a pump capable or i) and ii), wherein said control channel is capable of controlling fluid in said flow channels in an adjacent said microfluidic layer by closing and opening said channels in said adjacent microfluidic layer.

6. The integrated microfluidic biochip of claim 1, wherein each said independent surface sensor comprises an independent capture molecule for detecting separate analytes.

7. The integrated microfluidic biochip of claim 1, wherein said surface sensors comprise a range of sizes.

8. The integrated microfluidic biochip of claim 1, wherein said hollow structures are capable of isolating individual said surface sensors or groups of said surface sensors from other said surface sensors on said sensor plate.

9. The integrated microfluidic biochip of claim 1, wherein said surface sensors are disposed in an array of said surface sensors.

10. The integrated microfluidic biochip of claim 1, wherein said microfluidic device comprises microfluidic valves, wherein said microfluidic valves are capable of dynamically programming said hollow structures.