IN-VIVO DEVICE, SYSTEM AND METHOD FOR DETECTION OF HELICOBACTER PYLORI
First Claim
1. An in-vivo device for in-vivo detection of H. pylori, said device comprising:
- a housing;
a reference electrode disposed on the housing;
a working electrode disposed on the housing in close proximity to said reference electrode, said working electrode coated by litography or screen printing with salt dissolvable in the presence of ammonia such that substantially no current can pass between the working electrode and the reference electrode when coated;
a measuring device for measuring current, impedance and/or resistance between the working and the reference electrodes; and
a transmitter for transmitting said measurements .
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Accused Products
Abstract
Device, system and method for in-vivo detection of H. pylori. For example, an in-vivo device includes a housing, a reference electrode disposed on the housing, and a working electrode disposed on the housing in close proximity to the reference electrode. The working electrode is coated by litography or screen printing with salt such that substantially no current passes between the working electrode and the reference electrode. The in-vivo device further includes a measuring device for measuring current, impedance, and/or resistance between the working and the reference electrodes, and a transmitter for transmitting the measurements. Presence of ammonia, which is a byproduct of H. pylori, causes increase in current and thus decrease in impedance or resistance between the reference electrode and the working electrode; thereby measurements of current, impedance, and/or resistance indicate on presence or absence of H. pylori.
9 Citations
16 Claims
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1. An in-vivo device for in-vivo detection of H. pylori, said device comprising:
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a housing; a reference electrode disposed on the housing; a working electrode disposed on the housing in close proximity to said reference electrode, said working electrode coated by litography or screen printing with salt dissolvable in the presence of ammonia such that substantially no current can pass between the working electrode and the reference electrode when coated; a measuring device for measuring current, impedance and/or resistance between the working and the reference electrodes; and a transmitter for transmitting said measurements . - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. An in-vivo device for in-vivo detection of H. pylori, said device comprising:
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a housing; a gap through which in-vivo fluids may enter and exit; a mixture of substrate and enzyme for reacting with ammonia, which causes the substrate to change its optical properties; an illumination source for illuminating said mixture, said illumination source located on one side of the gap; a detector for detecting the change in optical properties of the substrate that indicate presence of H. pylori, wherein said detector is located on an opposite side of the gap and facing across the gap towards the illumination source; and a transmitter for transmitting said detected changes in optical properties that indicate presence of H. pylori. - View Dependent Claims (11, 12, 13)
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14. A method for in-vivo detection of H. pylori, said method comprising the following steps:
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administering into gastric fluids a swallowable in-vivo device comprising a reference electrode, a working electrode litography coated with salt, and an ampere-meter; measuring current between the reference and working electrodes using said ampere-meter; and determining presence of H. pylori in-vivo based on said current measurements. - View Dependent Claims (15)
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16. A method for in-vivo detection of H. pylori, said method comprising the following steps:
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administering in-vivo a swallowable device, said device comprising;
a gap, an illumination source located on one side of the gap, a detector located on the opposite side of the gap and facing across the gap towards said illumination source, and a substrate and enzyme located within the gap for detection of ammonia;allowing flow of in-vivo fluids through the gap, and thus allowing contact between the substrate, enzyme, and ammonia; and determining in-vivo presence of H. pylori, based on change in optical properties of the substrate.
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Specification