SPECTROMETRIC SYSTEMS AND METHODS FOR IMPROVED FOCUS LOCALIZATION OF TIME- AND SPACE-VARYING MEASUREMENTS
First Claim
1. A method for determining a characteristic of a biological sample with a spectrometric system, the spectrometric system including at least one transmitter and at least one receiver, the method comprising:
- receiving, with a data-processing unit of the system, an output from the at least one receiver caused by emission, by the transmitter, of at least one electromagnetic wave (EMW) at at least one corresponding wavelength, the at least one transmitter and the at least one receiver being operably juxtaposed with the sample, the output representing an optical property of the sample;
receiving, with the data-processing unit of the system, reference data representing empirically-defined spectrally-dependent characteristic of the sample;
determining an impulse response of the sample, the impulse response being associated with emission of the at least one EMW by the at least one transmitter; and
determining, as a function of time, a wavelength-dependent material parameter characterizing the sample based on the determined impulse response and the reference data
1 Assignment
0 Petitions
Accused Products
Abstract
A system and method of dynamically localizing a measurement of parameter characterizing tissue sample with waves produced by spectrometric system at multiple wavelengths and detected at a fixed location of the detector of the system. The parameter is calculated based on impulse response of the sample, reference data representing characteristics of material components of the sample, and path lengths through the sample corresponding to different wavelengths. Dynamic localization is effectuated by considering different portions of a curve representing the determined parameter, and provides for the formation of a spatial map of distribution of the parameter across the sample. Additional measurement of impulse response at multiple detectors facilitates determination of change of the measured parameter across the sample as a function of time.
-
Citations
18 Claims
-
1. A method for determining a characteristic of a biological sample with a spectrometric system, the spectrometric system including at least one transmitter and at least one receiver, the method comprising:
-
receiving, with a data-processing unit of the system, an output from the at least one receiver caused by emission, by the transmitter, of at least one electromagnetic wave (EMW) at at least one corresponding wavelength, the at least one transmitter and the at least one receiver being operably juxtaposed with the sample, the output representing an optical property of the sample; receiving, with the data-processing unit of the system, reference data representing empirically-defined spectrally-dependent characteristic of the sample; determining an impulse response of the sample, the impulse response being associated with emission of the at least one EMW by the at least one transmitter; and determining, as a function of time, a wavelength-dependent material parameter characterizing the sample based on the determined impulse response and the reference data - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method for operating a spectrometric device configured to generate electromagnetic waves (EMWs) and juxtaposed with a sample such as to measure at least one property associated with at least one material component of the sample using at least one of the EMWs, the method comprising:
-
in response to a first excitation sequence of pulses generated by a unit of the spectrometric device, transmitting a first EMW at a first wavelength by a transmitter associated with the spectrometric device; concurrently with transmitting the first EMW and in response to a second excitation sequence of pulses generated by the unit of the spectrometric device, transmitting a second EMW at a second wavelength by a transmitter associated with the spectrometric device; acquiring said first and second transmitted EMWs as an aggregated input with a receiver associated with the spectrometric device; and processing the received aggregated input with a data-processing unit associated with the spectrometric device by; correlating the aggregated input with a time-controlled representation of the first excitation sequence of pulses to form a time based vector; correlating the aggregated input with a time-controlled representation of the second excitation sequence of pulses to form a second time-based vector; calculating, based at least on first and second time based vector, the at least one property associated with the at least one material components of the sample.
-
-
11. An optical-path adjustment apparatus for modifying an optical path between a source of light and a receiver of light, the apparatus comprising:
-
the source of light including at least one transmitter enabled to emit a corresponding beam light at at least one corresponding wavelength; the receiver of light in optical communication with the at least one transmitter; and a device including a first plurality of selectively reorientable reflectors disposed such that, when each of the reflectors from the first plurality is in a corresponding reference orientation, the first plurality defines a first surface; a second plurality of selectively reorientable reflectors disposed such that, when each of the reflectors from the second plurality is in a corresponding reference orientation, the second plurality defines a second surface that is transverse to the first surface and substantially parallel to the corresponding beam of light, the first and second pluralities being in optical communication with the at least one transmitter such as to enable the apparatus to scan the corresponding beam of light which, when a reflector of the first plurality and a reflector of the second plurality are reoriented with respect to the corresponding reference orientations, has interacted with the reflector of the first plurality after having interacted with the reflector of the second plurality. - View Dependent Claims (12, 13, 14, 15, 16)
-
-
17. An optical-data-collection apparatus comprising:
-
an optical detector; a light irradiation system enabled to deliver a beam of light from a starting point to the optical detector such as to scan an object that has been positioned at an intermediate point along a direction of propagation of the beam between the starting point and the optical detector, the light irradiation system including at least one light transmitter defining the starting point, and a plurality of spatially reorientable reflectors disposed such that, when at least three of said reflectors are in respectively corresponding reference states of orientation, the at least three of said reflector define a plane that is substantially parallel to the beam of light, wherein the light irradiation system enables controlling a distance traversed by the delivered beam that has scanned the object by reflecting the beam with a reflector from the plurality to redirect the beam towards the optical detector. - View Dependent Claims (18)
-
Specification