METHODS, DEVICES, AND SYSTEMS FOR BLOOD FLOW

• US 20180098803A1
• Filed: 12/12/2017
• Published: 04/12/2018
• Est. Priority Date: 05/06/2016
• Status: Active Grant

• Current Assignee: Medos International Sarl (Johnson & Johnson)
• Original Assignee: Medos International Sarl (Johnson & Johnson)
• Inventors: Whittaker, Gregory R., Cleveland, Benjamin, Hwang, Julia, Spenciner, David B., Parrish, William R., Marks, Jacob A., Sengun, Mehmet Z., Bittenson, Steven N., Theis, Reagan A.
• Granted Patent: US 10,639,085 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/846 Nails or pins, i.e. anchors without movable parts, holding by friction only, with or without structured surface A61B17/72, A61B17/86 take precedence
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/0412 having anchoring barbs or pins extending outwardly from suture anchor body
• CPC Class Codes: A61B 2017/044 with a threaded shaft, e.g. screws
• CPC Class Codes: A61B 2017/0445 cannulated, e.g. with a longitudinal through-hole for passage of an instrument
• CPC Class Codes: A61B 2017/045 snug fit within the anchor
• CPC Class Codes: A61B 2017/0458 Longitudinal through hole, e.g. suture blocked by a distal suture knot
• CPC Class Codes: A61B 2017/561 Implants with special means for releasing a drug
• CPC Class Codes: A61F 2/0811 Fixation devices for tendons or ligaments
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/28 Materials for coating prostheses
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 25/0043 characterised by structural features

Abstract

Various exemplary methods, systems, and devices for blood flow are provided. In general, an implant can be configured to be implanted in bone and to delay clotting of blood flowing from the bone. The implant can include an anti-coagulation agent to delay the clotting of the blood. The anti-coagulation agent can be a coating on the implant, can be natural to a material forming the implant, or can be impregnated into a material forming the implant. In an exemplary embodiment, the implant is implanted in a bone in a surgical procedure for securing a soft tissue to bone, such as a rotator cuff repair procedure or an anterior cruciate ligament (ACL) repair procedure.

Claims

1. A surgical device, comprising:

a biocompatible tubular member configured to be implanted in a bone of a patient, the tubular member having a solid sidewall defining an inner lumen extending through the tubular member such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen, and the tubular member having an anti-coagulation agent on the solid sidewall.

2. The device of claim 1, wherein the inner lumen is open and free of occlusions.

3. The device of claim 1, wherein the inner lumen has a plug removably disposed therein that occludes the inner lumen such that the blood cannot flow out of the inner lumen through the second open end of the inner lumen until the plug is removed from the inner lumen, the plug being configured to be implanted in the patient with the tubular member.

4. The device of claim 3, wherein the plug has a suture extending therefrom, the suture being configured to extend from inside the patient'"'"'s body to outside the patient'"'"'s body and to be pulled from outside the patient'"'"'s body and thereby remove the plug from the inner lumen of the tubular member.

5. The device of claim 3, wherein the plug includes a knitted material that occludes the inner lumen until the knitted material is pulled to cause the knitted material to unravel.

6. The device of claim 3, wherein the plug is made from an energy activated material disposed therein that occludes the inner lumen until the energy activated material is activated by application of energy thereto.

7. The device of claim 1, wherein the inner lumen has a bioabsorbable material disposed therein that occludes the inner lumen such that the blood cannot flow out of the inner lumen through the second open end of the inner lumen until the bioabsorbable material has been at least partially absorbed by the patient'"'"'s body.

8. The device of claim 1, wherein the tubular member includes a retaining member configured to engage the bone in which the tubular member is implanted to retain the tubular member within the bone.

9. The device of claim 1, wherein the anti-coagulation agent is coated on a surface of the solid sidewall.

10. The device of claim 1, wherein the anti-coagulation agent is impregnated in a material forming the solid sidewall.

11. The device of claim 1, wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor.

12. The device of claim 1, wherein the tubular member is bioabsorbable.

13. The device of claim 1, wherein the tubular member is not bioabsorbable.

14. A surgical device, comprising:

a biocompatible anchor configured to be implanted in a bone of a patient, the anchor having at least one bone-engaging surface feature on an exterior surface thereof that is configured to engage the bone to secure the anchor in the bone, the anchor having an inner lumen extending therethrough such that blood can flow into the inner lumen through a first open end of the inner lumen and out of the inner lumen through a second open end of the inner lumen when the anchor is implanted in the bone, and the anchor including an anti-coagulation agent.

15. The device of claim 14, wherein the anti-coagulation agent is coated on a surface of the anchor.

16. The device of claim 14, wherein the anti-coagulation agent is impregnated in a material forming the anchor.

17. The device of claim 14, wherein the anti-coagulation agent includes at least one of heparin, heparin sulfate, warfarin, hirudin, hirulog, coumarin, phosphorylcholine, indiandione, antithrombin III, bemiparin, dalteparin, danaparoid, enoxaparin, nadroparin, parnaparin, reviparin, sulodexide, tinzaparin, anticoagulant citrate dextrose solution A (ACD-A), ethylenediaminetetraacetic acid (EDTA), citrate, oxalate, a factor Xa inhibitor, and a thrombin inhibitor.