ANTI-SCLEROSTIN ANTIBODY, ANTIGEN BINDING FRAGMENT AND MEDICAL USE THEREOF
First Claim
Patent Images
1. An antibody or antigen-binding fragment thereof that specifically binds to human sclerostin, comprising:
- a heavy chain variable region HCDR sequence comprising amino acid sequences of SEQ ID NO;
7, SEQ ID NO;
8 or SEQ ID NO;
9, or a mutant sequence thereof, or an amino acid sequence having at least 95% sequence identity thereto; and
a light chain variable region LCDR sequence comprising amino acid sequences of SEQ ID NO;
10, SEQ ID NO;
11 or SEQ ID NO;
12, or a mutant sequence thereof, or an amino acid sequence having at least 95% sequence identity thereto.
1 Assignment
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Accused Products
Abstract
Provided is a humanized antibody and chimeric antibody that specifically binds human sclerostin. The antibodies can be used for treating human bone metabolism related diseases such as osteoporosis (OP).
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Citations
31 Claims
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1. An antibody or antigen-binding fragment thereof that specifically binds to human sclerostin, comprising:
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a heavy chain variable region HCDR sequence comprising amino acid sequences of SEQ ID NO;
7, SEQ ID NO;
8 or SEQ ID NO;
9, or a mutant sequence thereof, or an amino acid sequence having at least 95% sequence identity thereto; anda light chain variable region LCDR sequence comprising amino acid sequences of SEQ ID NO;
10, SEQ ID NO;
11 or SEQ ID NO;
12, or a mutant sequence thereof, or an amino acid sequence having at least 95% sequence identity thereto. - View Dependent Claims (5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 29, 30, 31)
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2-4. -4. (canceled)
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9. (canceled)
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16. (canceled)
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27. (canceled)
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28. (canceled)
Specification