COMPOSITIONS AND METHODS FOR STABILIZATION OF RETINOIDS

• US 20190307662A1
• Filed: 04/08/2019
• Published: 10/10/2019
• Est. Priority Date: 04/06/2018
• Status: Active Grant

• Current Assignee: Medik8 Limited
• Original Assignee: Pangaea Laboratories Ltd.
• Inventors: Isaacs, Daniel, Isaacs, Elliot, Murugesan, Kavitha
• Granted Patent: US 10,864,148 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 8/06 Emulsions
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/31 Hydrocarbons
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 8/738 Cyclodextrins
• CPC Class Codes: A61K 8/84 obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
• CPC Class Codes: A61K 8/88 Polyamides
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The present invention relates to a composition and method for stabilisation of compounds including retinoids using the synergistic effects of beta-carotene and sodium polyaspartate.

Claims

1. A cosmetic composition comprising beta-carotene and sodium polyaspartate.

2. A cosmetic composition according to claim 1 wherein the beta-carotene is selected from synthetic beta-carotene, isolated beta-carotene or a plant extract containing beta-carotene.

3. A cosmetic composition according to claim 2 wherein the ratio of synthetic beta carotene or isolated beta carotene to sodium polyaspartate is 1:

0.1 to 1;

10.

4. A cosmetic composition according to claim 2 wherein the plant extract is from carrot.

5. A cosmetic composition according to claim 4 wherein the carrot extract is selected from carrot root extract and carrot seed oil extract.

6. A cosmetic composition according to claim 5 wherein the ratio of carrot extract to sodium polyaspartate is 100:

1 to 10;

1.

7. A cosmetic composition according to claim 6 wherein the ratio of carrot extract to sodium polyaspartate is 40:

1 to 15;

1.

8. A cosmetic composition according claim 1 further comprising retinaldehyde.

9. A cosmetic composition according to claim 8 wherein the concentration of retinaldehyde is up to 0.1% weight, wherein the weight percentage is based on total composition weight.

10. A cosmetic composition according to claim 8 wherein the retinaldehyde is cyclodextrin encapsulated.

11. A stabilising composition comprising beta-carotene, sodium polyaspartate and retinaldehyde wherein the beta-carotene and sodium polyaspartate stabilise the retinaldehyde.

12. A stabilising composition according to claim 11 wherein the beta-carotene is selected from synthetic beta-carotene, isolated beta-carotene or a plant extract containing beta-carotene.

13. A method of stabilising retinaldehyde, the method comprising providing a composition comprising beta-carotene, sodium polyaspartate and, retinaldehyde.

14. A method according to claim 13 wherein the beta-carotene is selected from synthetic beta-carotene, isolated beta-carotene or a plant extract containing beta-carotene.

15. A method according to claim 14 wherein the ratio of synthetic beta carotene or isolated beta carotene to sodium polyaspartate is 1:

0.1 to 1;

10.

16. A method according to claim 14 wherein the plant extract is from carrot.

17. A method according to claim 16 wherein the carrot extract is selected from carrot root extract and carrot seed oil extract.

18. A method according to claim 17 wherein the ratio of carrot extract to sodium polyaspartate is 100:

1 to 10;

1.

19. A method according to claim 17 wherein the ratio of carrot extract to sodium polyaspartate is 40:

1 to 15;

1.

20. A method according to claim 13 wherein the concentration of retinaldehyde is up to 0.1% weight, wherein the weight percentage is based on total composition weight.