Dosage form comprising means for changing drug delivery shape
First Claim
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1. A dosage form for delivering a dose of 0.5 mg to 650 mg of a drug comprising a particle size of up to 5 microns, wherein the dosage form comprises a membrane that defines the shape of the dosage form, said membrane comprising a means for changing the shape of the dosage form from a non-rounded dosage form to a rounded dosage form that enhances the delivery of the drug at a controlled and sustained rate over an extended time.
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Abstract
A dosage form is disclosed comprising means for delivering essentially a total dose of drug.
44 Citations
6 Claims
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1. A dosage form for delivering a dose of 0.5 mg to 650 mg of a drug comprising a particle size of up to 5 microns, wherein the dosage form comprises a membrane that defines the shape of the dosage form, said membrane comprising a means for changing the shape of the dosage form from a non-rounded dosage form to a rounded dosage form that enhances the delivery of the drug at a controlled and sustained rate over an extended time.
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2. A dosage form for delivering a maximum dose of 0.5 mg to 650 mg of a drug in vivo, wherein the dosage form comprises means for changing the shape of the dosage form as shown in FIG. 6 from shape 12a to shape 12b, whereby less drug is maintained in the dosage form for delivering the maximum dose of 0.5 mg to 650 mg of the drug over an extended time.
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3. A process for increasing the dose of drug delivered from a dosage form possessing controlled-sustained release delivery, wherein the dosage form comprises:
- a membrane and a dose of drug, and wherein the process comprises;
blending means with the membrane for making the membrane flexible and distensible;
shaping the membrane to provide a shaped membrane; and
changing the dosage form from a non-rounded dosage form to a rounded dosage form thereby increasing the dose of drug delivered at a controlled-release rate from the dosage form.
- a membrane and a dose of drug, and wherein the process comprises;
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4. A method for administering the maximum dose of a drug to a patient, wherein the method comprises administering orally to the patient a controlled-sustained release dosage form comprising:
- a dose of 0.5 mg to 650 mg of a drug, and a membrane comprising a means for changing the dosage form from a non-rounded dosage form to a rounded dosage form for delivering the maximum dose of 0.5 mg to 650 mg of the drug at a controlled-sustained release rate over an extended time.
- View Dependent Claims (5, 6)
Specification