Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications
First Claim
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1. A method of treating cells, tissues or organs comprising:
- implanting an in vivo plasma separation device within a blood vessel of a patient or donor;
separating blood plasma from whole blood in vivo using said plasma separation device;
directing said plasma from the plasma separation device to a bioreactor; and
exposing said plasma to cells, tissue or organ in said bioreactor.
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Abstract
The present invention is directed to a method of treating cells, tissues or organs using in vivo plasma separation by implanting a plasma separation filter device within a blood vessel of a patient, or allogenic, or xenogenic donor, continuously separating blood plasma from whole blood in vivo, directing the plasma from the plasma separation filter device to a bioreactor, and exposing the plasma to cells, tissue or an organ within the bioreactor utilizing immune separation membranes where necessary.
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Citations
32 Claims
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1. A method of treating cells, tissues or organs comprising:
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implanting an in vivo plasma separation device within a blood vessel of a patient or donor;
separating blood plasma from whole blood in vivo using said plasma separation device;
directing said plasma from the plasma separation device to a bioreactor; and
exposing said plasma to cells, tissue or organ in said bioreactor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. An apparatus for carrying out a method of treating cells, tissues or organs comprising:
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a filter for being planted in a patient'"'"'s blood vessel comprising a plurality of elongated hollow microporous fibers having an interior lumen and a fiber wall having a pore size capable of allowing plasma to diffuse therethrough, wherein said fibers comprise a fiber wall having a plurality of zones between the inner and outer wall surfaces, each of said zones having a mass density different than the mass density of an adjacent zone, said fiber wall characterized by having a lower mass density zone at the inner wall surface and a higher mass density zone at the outer wall surface;
a multiple lumen catheter in fluid communication with the interior fiber lumen including a first lumen for directing separated blood plasma from said fiber lumen and a second lumen for directing blood plasma to the patient;
a bioreactor; and
a first conduit for directing plasma from the first lumen to said bioreactor, and a second conduit for directing exposed plasma from said bioreactor to the second lumen. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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Specification