Method and apparatus for measuring analytes in blood bags
First Claim
1. A method for determining a concentration of one, or more than one analyte in a sample contained in a blood bag or in a tubing in fluid communication with said blood bag, using an instrument comprising one, or more than one calibration algorithm for said one, or more than one analyte, said method comprising:
- a) irradiating said sample in said tubing, or said blood bag, using a radiation source of about 475 nm to about 2,700 nm;
b) measuring an absorbance of said sample; and
c) calculating a concentration of said one, or more than one analyte using said absorbance and said one, or more than one calibration algorithm.
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Abstract
The present invention provides a method for determining a concentration of at least one analyte in a sample contained in a blood bag or in tubing in fluid communication with said blood bag, using an instrument comprising at least one calibration algorithm for the at least one analyte. The method comprises irradiating a sample in the tubing or the blood bag, using a near infrared and adjacent visible radiation source. Then measuring absorbance from the sample for the at least one analyte, and calculating a concentration of the at least one analyte using the absorbance and the at least one calibration algorithm.
17 Citations
8 Claims
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1. A method for determining a concentration of one, or more than one analyte in a sample contained in a blood bag or in a tubing in fluid communication with said blood bag, using an instrument comprising one, or more than one calibration algorithm for said one, or more than one analyte, said method comprising:
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a) irradiating said sample in said tubing, or said blood bag, using a radiation source of about 475 nm to about 2,700 nm; b) measuring an absorbance of said sample; and c) calculating a concentration of said one, or more than one analyte using said absorbance and said one, or more than one calibration algorithm. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for determining a concentration of one, or more than one of haemoglobin, bilirubin, biliverdin, equivalent intralipid, methylene blue and cross-linked haemoglobinin in a sample contained in a blood bag or in a tubing in fluid communication with said blood bag, using an instrument comprising one, or more than one calibration algorithm for each of said haemoglobin, bilirubin, biliverdin, equivalent intralipid, methylene blue and cross-linked haemoglobin, said method comprising:
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a) irradiating said sample in said tubing or said blood bag using a radiation source of about 475 nm to about 2,700 nm; b) measuring an absorbance of said sample, and c) calculating a concentration for one, or more than one of said haemoglobin, bilirubin, biliverdin, equivalent intralipid, methylene blue and cross-linked haemoglobin by determining values of first derivatives of two, or more than two portions of a spectrum generated from said step of measuring (step b), and incorporating said first derivatives into said one, or more than one calibration algorithm to provide said concentration.
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Specification