Compositions and methods for topical treatment of skin infection

• US 7,258,875 B2
• Filed: 12/04/2003
• Issued: 08/21/2007
• Est. Priority Date: 12/04/2003
• Status: Expired due to Fees

• Current Assignee: Chiou Consulting Incorporated
• Original Assignee: Chiou Consulting Incorporated
• Inventors: Chiou, Win L.
• Primary Examiner(s): HUI, SAN MING R
• Application Number:
  US10/727,376
• Publication Number:
  US 20050123620A1
• Time in Patent Office: 1,356 Days
• Field of Search: 424/639, 424/641, 424/647
• US Class Current: 424/641
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/34 Copper; Compounds thereof
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 17/12 Keratolytics, e.g. wart or anti-corn preparations
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/12 Antivirals

Abstract

The present invention describes an extremely effective, simple, novel, inexpensive, safe and quick method to treat both acne and warts, each with a different etiology and different clinical symptoms, by topically applying an effective amount of one or more polyvalent metal compounds. The polyvalent metal compounds include, but are not limited to, bismuth compounds, zinc compounds, magnesium compounds, aluminum compounds, calcium compounds, copper compounds, titanium compounds, manganese compounds, chromium compounds, barium compounds and iron compounds. The present invention can also be applied to the treatment of rosacea. The present invention can also be employed to prevent scarring and to facilitate healing or elimination of the scars once formed.

Claims

1. A method for ameliorating acne comprising topically applying a therapeutically effective amount of one or more aluminum compounds selected from the group of aluminum potassium sulfate, and aluminum ammonium sulfate in a pharmaceutically acceptable dosage form to the area of lesion of the acne.

3. The method of claim 1, wherein the concentration of the aluminum compound ranges from about 0.05% to about 50% by weight.

2. A method for ameliorating acne consisting essentially of topically applying a therapeutically effective amount of one or more aluminum compounds selected from the group of aluminum potassium sulfate, and aluminum ammonium sulfate in a pharmaceutically acceptable dosage form to the area of the lesion of the acne, wherein the concentration of the aluminum compound ranges from about 0.05% to about 50% by weight.

4. A method for ameliorating rosacea comprising topically applying a therapeutically effective concentration of one or more aluminum compounds selected from the group consisting of aluminum potassium sulfate, aluminum sulfate, aluminum lactate and aluminum ammonium sulfate in a pharmaceutically acceptable dosage form to the area of lesion of the rosacea.

5. The method of claim 4, wherein the concentration of the aluminum compound ranges from about 0.05% to about 50% by weight.

6. A method for ameliorating rosacea comprising topically applying a therapeutically effective concentration of one or more bismuth compounds selected from the group consisting of bismuth subsalicylate, bismuth subcarbonate, bismuth subgallate, bismuth subsaltrate, bismuth phosphate, bismuth aluminate, bismuth salicylate, bismuth tribromophenate, bismuth dipropylacetate, bismuth citrate, bismuth subcitrate, bismuth ascorbate, bismuth subcarbonate, bismuth tartrate and colloidal bismuth subcitrate in a pharmaceutically acceptable dosage form to the area of lesion of the rosacea.

7. The method of claim 6, wherein the concentration of the bismuth compound ranges from about 0.05% to about 5% by weight.

8. A method for ameliorating warts in human comprising topically applying a therapeutically effective amount of one or more polyvalent metal compounds in a pharmaceutically acceptable dosage form to the area of the lesion of warts, wherein a metal compound is selected from the group consisting of aluminum potassium sulfate aluminum lactate, aluminum ammonium sulfate, bismuth subsalicylate, bismuth chloride, bismuth oxide, bismuth subcarbonate, bismuth subgallate, bismuth subsaltrate, bismuth phosphate, bismuth aluminate, bismuth tribromophenate, bismuth dipropylacetate, bismuth citrate, bismuth subcitrate, bismuth ascorbate, bismuth tartrate and colloidal bismuth subcitrate.

9. The method of claim 8, wherein the concentration of the polyvalent metal compound ranges from about 0.05% to about 50% by weight.

10. A method for ameliorating warts in human consisting essentially of topically applying a therapeutically effective amount of one or more polyvalent metal compounds in a pharmaceutically acceptable dosage form to the area of the lesion of warts, wherein a metal compound is selected from the group consisting of aluminum potassium sulfate, aluminum lactate, aluminum ammonium sulfate, bismuth subsalicylate, bismuth chloride, bismuth oxide, bismuth subcarbonate, bismuth subgallate, bismuth subsaltrate, bismuth phosphate, bismuth aluminate, bismuth tribromophenate, bismuth dipropylacetate, bismuth citrate, bismuth subcitrate, bismuth ascorbate, bismuth tartrate and colloidal bismuth subcitrate, wherein the concentration of the metal compound ranges from about 0.05% to about 50% by weight.