Detection and characterization of cholinergic oscillatory control in peripheral microvasculature
First Claim
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1. A method of selectively identifying frequency and power of cholinergic oscillatory activity in microvasculature of a human comprising:
- a). measuring the frequency and power of the oscillatory activity in the microvasculature of the human at a frequency of from about 0.12 Hz to about 0.18 Hz; and
b). distinguishing the measured activity obtained in step a) from the sympathetic oscillatory activity and the proximally generated parasympathetic oscillatory activity, thereby selectively identifying the frequency and power of the cholinergic oscillatory activity.
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Abstract
The present invention is an apparatus and method for assessing the condition of a subject by measuring and characterizing one or more oscillatory activities of the subject. The oscillatory activities are under the control of the autonomic nervous system and characterizing the activities provides information related to the status of the autonomic nervous system.
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Citations
28 Claims
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1. A method of selectively identifying frequency and power of cholinergic oscillatory activity in microvasculature of a human comprising:
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a). measuring the frequency and power of the oscillatory activity in the microvasculature of the human at a frequency of from about 0.12 Hz to about 0.18 Hz; and b). distinguishing the measured activity obtained in step a) from the sympathetic oscillatory activity and the proximally generated parasympathetic oscillatory activity, thereby selectively identifying the frequency and power of the cholinergic oscillatory activity. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of assessing cholinergic oscillatory activity of a subject comprising:
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a). measuring the frequency and power of the oscillatory activity of a cardiovascular signal in the microvasculature of the subject at a frequency from about 0.12 Hz to about 0.18 Hz; and b). distinguishing the measured activity obtained in step a) from the sympathetic oscillatory activity and the proximally generated parasympathetic oscillatory activity, thereby selectively identifying the frequency and power of the cholinergic oscillatory activity in the microvasculature, and c). assessing the condition of the subject, wherein the cholinergic oscillatory activity is indicative of an autonomic dysfunction, an autonomic neuropathy, a prehypertensive state, a hypertensive state, a decrease in parasympathetic activity, and diabetes. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification