Method of constructing a biosensor

• US 7,529,574 B2
• Filed: 08/14/2003
• Issued: 05/05/2009
• Est. Priority Date: 08/14/2003
• Status: Expired due to Term

• Current Assignee: Konamite Limited
• Original Assignee: Isense Corporation
• Inventors: Jansen, Lawrence B., Ward, W. Kenneth, Anderson, Ellen
• Primary Examiner(s): NASSER, ROBERT L
• Application Number:
  US10/640,980
• Publication Number:
  US 20050038330A1
• Time in Patent Office: 2,091 Days
• Field of Search: None
• US Class Current: 600/345
• CPC Class Codes: A61B 2562/125 characterised by the manufacture of electrodes
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors

Abstract

A method of creating an analyte sensor. The method starts with the step of providing an electrochemically active surface. Then, at least one nub made of dielectric material and extending transversely outwardly from the electrochemically active surface is created. A curable liquid is applied to the electrochemically active surface and the nub and is then cured. In this process, the nub, which could be one of several nubs, serves to support the liquid before and during the curing.

Claims

1. An indwelling analyte sensor, comprising:

an electrochemically active surface;

at least two nubs of dielectric material extending outwardly from said electrochemically active surface and forming a cavity along said electrochemically active surface and between said at least two nubs; and

a membrane system comprising an enzyme layer, said enzyme layer surrounding said at least two nubs and said electrochemically active surface at least along said cavity.

2. The sensor of claim 1, wherein at least one of said at least two nubs is in the form of a plate.

3. The sensor of claim 1, wherein at least one of said at least two nubs comprises an annular plate.

4. The sensor of claim 1, wherein said electrochemically active surface is defined as part of a lengthwise body.

5. The sensor of claim 4, wherein said lengthwise body is circular in cross-section.

6. The sensor of claim 1, wherein at least one of said at least two nubs is displaced longitudinally from said electrochemically active surface.

7. The sensor of claim 1, wherein said membrane system includes multiple membranes.

8. The sensor of claim 1, wherein said membrane system defines an external surface of said sensor.

9. An indwelling analyte sensor, comprising:

an electrochemically active surface defining a sensing region along a portion of said electrochemically active surface;

a plurality of nubs of dielectric material extending outwardly from said electrochemically active surface, said plurality of nubs spaced along said electrochemically active surface; and

a membrane system comprising an enzyme layer, said enzyme layer surrounding said sensing region of said electrochemically active surface to form an active sensing region and surrounding said plurality of nubs.

10. The sensor of claim 9, wherein said electrochemically active surface extends through at least two of said plurality of nubs.

11. The sensor of claim 9, wherein said membrane system defines a substantially catenary curve-shaped surface between at least two of said plurality of nubs.

12. The sensor of claim 9, wherein said membrane system has an outer surface and said outer surface defines a concave curve curving toward said electrochemically active surface between at least two of said plurality of nubs.

13. The sensor of claim 9, wherein at least one of said at least two nubs is in the form of a plate.

14. The sensor of claim 9, wherein at least one of said at least two nubs comprises an annular plate.

15. The sensor of claim 9, wherein said electrochemically active surface is defined as part of a lengthwise body.

16. The sensor of claim 15, wherein said lengthwise body is circular in cross-section.

17. The sensor of claim 9, wherein at least one of said at least two nubs is displaced longitudinally from said electrochemically active surface.

18. The sensor of claim 9, wherein said membrane system includes multiple membranes.

19. The sensor of claim 9, wherein said membrane system defines an external surface of said sensor.