Feedback method for deep brain stimulation with detection of generalized efference copy signals
First Claim
1. A method of treating a patient suffering from chronic pain and/or generalized seizures, said method comprising:
- selecting a patient suffering from chronic pain and/or generalized seizures;
applying electrical stimulation to at least a portion of the patient'"'"'s subcortical structures involved in the generation and control of generalized efference copy signals under conditions effective to treat the patient'"'"'s chronic pain and/or generalized seizures;
detecting generalized efference copy signals of the patient; and
controlling said applying electrical stimulation in response to detected generalized efference copy signals of the patient.
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Accused Products
Abstract
Disclosed is a method for improving cognitive function or for improving coordination of function across a patient'"'"'s cortical regions. The method includes applying electrical stimulation to at least a portion of the patient'"'"'s subcortical structures involved in the generation and control of generalized efference copy signals. Internally generated movement of the patient is then detected and, in response to such internally generated movement, application of electrical stimulation is controlled. The method of the present invention has a number of benefits, including increasing flexibility in identifying targets for stimulation, improving the probability of successfully treating brain injury, and permitting patient biofeedback and self-regulation.
62 Citations
49 Claims
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1. A method of treating a patient suffering from chronic pain and/or generalized seizures, said method comprising:
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selecting a patient suffering from chronic pain and/or generalized seizures; applying electrical stimulation to at least a portion of the patient'"'"'s subcortical structures involved in the generation and control of generalized efference copy signals under conditions effective to treat the patient'"'"'s chronic pain and/or generalized seizures; detecting generalized efference copy signals of the patient; and controlling said applying electrical stimulation in response to detected generalized efference copy signals of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of treating a patient suffering from a brain injury, said method comprising:
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selecting a patient suffering from a brain injury; applying electrical stimulation to at least a portion of the patient'"'"'s subcortical structures involved in the generation and control of generalized efference copy signals under conditions effective to treat the patient'"'"'s brain injury; detecting generalized efference copy signals of the patient; and controlling said applying electrical stimulation in response to detected generalized efference copy signals of the patient. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method of treating a patient suffering from post-encephalitic parkinsonism, said method comprising:
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selecting a patient suffering from post-encephalitic parkinsonism; applying electrical stimulation to at least a portion of the patient'"'"'s subcortical structures involved in the generation and control of generalized efference copy signals under conditions effective to treat the patient'"'"'s post-encephalitic parkinsonism; detecting generalized efference copy signals of the patient; and controlling said applying electrical stimulation in response to detected generalized efference copy signals of the patient. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40)
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41. A method of treating a patient suffering from oculogyric crises, said method comprising:
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selecting a patient suffering from oculogyric crises; applying electrical stimulation to at least a portion of the patient'"'"'s subcortical structures involved in the generation and control of generalized efference copy signals under conditions effective to treat the patient'"'"'s oculogyric crises; detecting generalized efference copy signals of the patient; and controlling said applying electrical stimulation in response to detected generalized efference copy signals of the patient. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49)
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Specification