Implantable, tissue conforming drug delivery device
First Claim
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1. A drug delivery device for implantation into a patient comprising:
- a first device element which comprises a first substrate having a first plurality of discrete reservoirs disposed therein and at least a second device element which comprises a second substrate having a second plurality of discrete reservoirs disposed therein, said reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, anda flexible supporting layer,wherein the first and second device elements are attached to or integral with the flexible supporting layer such that drug molecules are releasable from each of the first and second pluralities of discrete reservoirs independent of drug molecules release from the other of the first and second pluralities of discrete reservoirs,whereby the drug delivery device is conformable to a curved body tissue surface.
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Abstract
A drug delivery device for implantation into a patient is provided that includes at least one device element that includes a substrate having a plurality of discrete reservoirs disposed therein, the reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, wherein the drug delivery device is adapted to conform to a curved bone tissue surface. In one embodiment, the substrate is flexible and conforms to a bone tissue surface. In another embodiment, the device has two or more device elements attached to or integral with a flexible supporting layer.
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Citations
29 Claims
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1. A drug delivery device for implantation into a patient comprising:
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a first device element which comprises a first substrate having a first plurality of discrete reservoirs disposed therein and at least a second device element which comprises a second substrate having a second plurality of discrete reservoirs disposed therein, said reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, and a flexible supporting layer, wherein the first and second device elements are attached to or integral with the flexible supporting layer such that drug molecules are releasable from each of the first and second pluralities of discrete reservoirs independent of drug molecules release from the other of the first and second pluralities of discrete reservoirs, whereby the drug delivery device is conformable to a curved body tissue surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A drug delivery device for implantation into a patient comprising:
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two or more device elements which each comprise a substrate having a plurality of discrete reservoirs disposed therein, said reservoirs containing therapeutic or prophylactic molecules and a degradable matrix material which controls in vivo release of the therapeutic or prophylactic molecules from the reservoirs, wherein the reservoirs of the plurality of discrete reservoirs in a first of said two or more device elements are discrete from the reservoirs of the plurality of discrete reservoirs in a second of said two or more device elements, and wherein the two or more device elements are flexibly connected together by tethers or hinges. - View Dependent Claims (21, 22)
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23. A method for delivering a drug to a site comprising:
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implanting at a site in a patient at least one drug delivery device which comprises at least two device elements, each comprising a substrate which has a plurality of discrete reservoirs containing a drug, each said reservoir having a release opening formed in a release side of said substrate, the at least two device elements being attached to or formed integral with a flexible supporting layer such that said release sides of said at least two device elements are positionable facing in confronting relationship to a body tissue surface, conforming the drug delivery device to a tissue surface at the site; and controllably releasing the drug from the discrete reservoirs. - View Dependent Claims (24, 25, 26)
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27. A drug delivery device for implantation into a patient comprising:
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at least two device elements, each of which comprises a substrate having a plurality of discrete reservoirs disposed therein, each said reservoir having a release opening formed in a release side of said substrate, said reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, the at least two device elements being attached to or integral with a flexible supporting layer such that both said release sides are positionable facing in confronting relationship to a body tissue surface, wherein the drug delivery device is conformable to a curved body tissue surface.
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28. A drug delivery device (50) for implantation into a patient comprising:
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two or more drug delivery device elements (54, 54), each device element comprising a substrate (60) having a plurality of discrete reservoirs (62) disposed therein, said reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, and a flexible supporting layer (52), and each said two or more drug delivery device elements (54, 54) being attached to or integral with said flexible supporting layer (52), wherein the drug delivery device is conformable to a curved body tissue surface.
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29. A drug delivery device for implantation into a patient comprising:
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at least two device elements, each of which comprises a substrate formed of a flexible polymeric material and having a plurality of discrete reservoirs disposed therein, each said reservoir having a release opening formed in a release side of said substrate, said reservoirs containing drug molecules and a degradable matrix material which controls in vivo release of the drug molecules from the reservoirs, and wherein the at least two device elements are attached to or integral with a flexible supporting layer such that both said release sides are positionable facing in confronting relationship to a body tissue surface.
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Specification