Redox polymers for use in electrochemical-based sensors

• US 7,592,151 B2
• Filed: 10/19/2007
• Issued: 09/22/2009
• Est. Priority Date: 07/28/2004
• Status: Active Grant

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Inventors: Rodgers, James Jain, Liu, Zuifang, Ulue, Geoffrey
• Primary Examiner(s): PEZZUTO, HELEN LEE
• Application Number:
  US11/875,681
• Publication Number:
  US 20080035479A1
• Time in Patent Office: 704 Days
• Field of Search: 525/279, 525/283, 525/297, 525/298, 435/4, 435/14, 435/817
• US Class Current: 435/14
• CPC Class Codes: C12Q 1/002 Electrode membranes
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: Y10S 435/817 Enzyme or microbe electrode

Abstract

A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer arm) attached to the hydrophobic polymer backbone. The redox polymer also includes a plurality of redox mediators (e.g., ferrocene-based redox mediators) attached to the at least one hydrophilic polymer arm.

Claims

1. An electrochemical-based sensor comprising:

an electrode; and

a chemical composition coated on a surface of the electrode, the chemical composition including a redox polymer with;

a hydrophobic polymer backbone;

at least one hydrophilic polymer arm attached to the hydrophobic polymer backbone, the hydrophilic polymer arm formed from at least one of N-vinylpyrrolidone, hydroxyethyl methacrylate, N-isopropylacrylamide, glycerol methacrylate, acrylamide, and combinations thereof; and

a plurality of redox mediators attached to the at least one hydrophilic polymer arm.

2. An electrochemical-based sensor comprising:

an electrode; and

a chemical composition coated on a surface of the electrode, the chemical composition including a redox polymer with;

a hydrophobic polymer backbone formed from at least one of methylmethacrylate, styrene, butyl methacrylate, and combinations thereof;

at least one hydrophilic polymer arm attached to the hydrophobic polymer backbone; and

a plurality of redox mediators attached to the at least one hydrophilic polymer arm.