Rapid analyte measurement assay
First Claim
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1. A method of measuring the concentration of a target analyte within a biological sample, the method comprising:
- applying the biological sample to an electrochemical cell having a redox reagent system comprising a first redox couple and at least one secondary redox couple, wherein the first redox couple is selected to mediate the target analyte;
applying a square wave excitation voltage across the electrochemical cell;
measuring a response current of the electrochemical cell, wherein the response current has a primary peak associated with mediation of the target analyte and one or more secondary peaks associated with the mediation of at least one secondary redox couple; and
determining the concentration of the target analyte within the biological sample based on the primary and secondary current peaks.
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Abstract
The present the invention provides methods, devices and systems for rapidly measuring analytes within a biological sample.
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Citations
17 Claims
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1. A method of measuring the concentration of a target analyte within a biological sample, the method comprising:
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applying the biological sample to an electrochemical cell having a redox reagent system comprising a first redox couple and at least one secondary redox couple, wherein the first redox couple is selected to mediate the target analyte; applying a square wave excitation voltage across the electrochemical cell; measuring a response current of the electrochemical cell, wherein the response current has a primary peak associated with mediation of the target analyte and one or more secondary peaks associated with the mediation of at least one secondary redox couple; and determining the concentration of the target analyte within the biological sample based on the primary and secondary current peaks. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system comprising:
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a test strip comprising an electrochemical cell having a redox reagent system comprising a first redox couple and at least one secondary redox couple, wherein the first redox couple is selected and configured to mediate the target analyte and provide a primary peak and the at least one secondary redox couple selected and configured so as to provide a secondary peak; and a meter configured for applying a square wave excitation voltage across the electrochemical cell and providing the primary peak and secondary peak, wherein the test strip is configured for electrical engagement with the meter. - View Dependent Claims (11, 12, 13)
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14. A device comprising:
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an electrochemical cell having a redox reagent system comprising a first redox couple and at least one secondary redox couple, wherein the first redox couple is selected and configured to mediate the target analyte and provide a primary peak and the at least one secondary redox couple selected and configured to provide a secondary peak; and a meter configured for applying a square wave excitation voltage across the electrochemical cell and providing the primary peak and the secondary peak, wherein the meter is in electrical communication with the electrochemical cell. - View Dependent Claims (15, 16, 17)
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Specification