Implantable heart valve prosthetic devices having intrinsically conductive polymers

• US 7,740,656 B2
• Filed: 11/17/2003
• Issued: 06/22/2010
• Est. Priority Date: 11/17/2003
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Coppin, Chris M., Capps, Mark J., Mensah, Eugene A., Gross, Jeffrey M.
• Primary Examiner(s): Stewart; Alvin J
• Application Number:
  US10/714,767
• Publication Number:
  US 20050107872A1
• Time in Patent Office: 2,409 Days
• Field of Search: 623 21- 242, 623/1.13, 623/1.24, 623/1.26
• US Class Current: 623/2.36
• CPC Class Codes: A61F 2/2403 with pivoting rigid closure members check valves with hinged closure members in general F16K15/03
• CPC Class Codes: A61F 2/2412 with soft flexible valve members, e.g. tissue valves shaped like natural valves check valves with flexible valve members in general F16K15/14
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08L 35/04 Homopolymers or copolymers of nitriles C08L35/06, C08L35/08 take precedence

Abstract

A heart valve sewing prosthesis including an intrinsically conductive polymer. The invention includes annuloplasty rings and bands, and sewing rings or cuffs for prosthetic heart valves. Some annuloplasty rings and sewing rings include fabric that is coated with an intrinsically conductive polymer. The coating can be formed over individual filaments or fibers, or on the fabric surface as a surface layer. One intrinsically conductive polymer is polypyrrole. The intrinsically conductive polymer can be doped to facilitate the intrinsic conductivity. Some devices have a polypyrrole surface layer doped with dialkyl-napthalene sulfonate. The intrinsically conductive polymer can be deposited on a fabric using in-situ polymerization of monomeric or oligomeric species, together with a dopant. Animal studies using implanted annuloplasty rings having an intrinsically conductive polymer coating have demonstrated a substantial reduction in pannus formation and inflammatory response.

Claims

1. An implantable heart valve sewing prosthesis comprising a ring shaped body having a blood contacting external surface including an intrinsically conductive polymer having a resistivity of less than about 2000 ohms per square, wherein the intrinsically conductive polymer is conductive without a metallic filler or coating.

2. The prosthesis of claim 1, wherein the ring shaped body is substantially closed upon itself.

3. The prosthesis of claim 1, wherein the ring shaped body has an annular gap and is not closed upon itself.

4. The prosthesis of claim 1, wherein the prosthesis is a prosthetic heart valve sewing ring.

5. The prosthesis of claim 4, wherein the prosthesis is a prosthetic heart valve sewing cuff.

6. The prosthesis of claim 1, wherein the external surface includes at least a part of a sheath of fabric, wherein the fabric incorporates the intrinsically conductive polymer.

7. The prosthesis of claim 1, wherein the polymer has a resistivity of less than 1000 ohms per square.

8. The prosthesis of claim 1, wherein the external surface includes a fabric having the polymer layer formed thereover.

9. The prosthesis of claim 8, wherein the fabric is formed of a plurality of individual filaments, and wherein the polymer layer is at least in part formed by a polymer coating over the individual filaments.

10. The prosthesis of claim 8, wherein the fabric is formed of a plurality of individual filament bundles formed of a plurality of filaments, and wherein the polymer layer is at least in part formed by a polymer coating over the individual filament bundles.

11. The prosthesis of claim 8, wherein the fabric is formed of a plurality of individual fibers formed of a plurality of filament bundles formed of a plurality of filaments, and wherein the polymer layer is at least in part formed by a polymer coating over the individual fibers.

12. The prosthesis of claim 8, wherein the polymer layer is a product of in situ polymerization on the fabric.

13. The prosthesis of claim 8, wherein the fabric is formed at least in part by filaments of integrally formed intrinsically conductive polymer.

14. The prosthesis of claim 8, wherein the polymer layer comprises polypyrrole.

15. The prosthesis of claim 8, wherein the polymer layer comprises a polypyrrole derivative.

16. The prosthesis of claim 8, wherein the polymer layer has a surface resistivity between about 10 and 1000 ohms per square.

17. The prosthesis of claim 8, wherein the polymer layer includes a polymer selected from polyaniline, polypyrrole, poly(vinylferrocene), polyacetylene, polythiophene, polybithiophene, and derivatives and combinations thereof.

18. The prosthesis of claim 8, wherein the polymer layer includes a polymer selected from polypyrrole and derivatives thereof.

19. The prosthesis of claim 18, wherein the polymer is doped with dialkyl-napthalene sulfonate.

20. An annuloplasty prosthesis for implanting in a heart valve annulus in a patient, the annuloplasty prosthesis comprising a ring shaped body comprising a blood contacting external surface comprising an intrinsically conductive polymer having a resistivity of less than about 2000 ohms per square, wherein the intrinsically conductive polymer is conductive without a metallic filler or coating.

21. The annuloplasty prosthesis of claim 20, wherein the external surface comprises fabric, wherein the fabric comprises an intrinsically conductive polymer.

22. The annuloplasty prosthesis of claim 20, wherein the intrinsically conductive polymer has a resistivity of less than 1000 ohms per square.