Biosensor, biosensor system and method of using thereof

• US 7,815,860 B2
• Filed: 11/23/2005
• Issued: 10/19/2010
• Est. Priority Date: 01/11/2005
• Status: Expired due to Fees

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Samsung Electronics Co. Ltd.
• Inventors: Kang, Jung-ho, Park, Tae-sik, Kim, Young-il
• Primary Examiner(s): Jung; Unsu
• Application Number:
  US11/286,030
• Publication Number:
  US 20060205060A1
• Time in Patent Office: 1,791 Days
• Field of Search: 435/4, 435/6, 435/7.1, 435/287.2, 435/287.9, 435/288.3, 422/68.1, 422 8201- 8202, 422/82.05, 436/147
• US Class Current: 422/82.01
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001

Abstract

A biosensor for detecting an analyte by using a variable voltage according to infrared radiation absorption is provided. The biosensor includes an infrared absorber having a variable resistance and bioreceptors immobilized onto the infrared absorber for selectively reacting and binding with an analyte, wherein an induced voltage at the infrared absorber varies depending on whether the bioreceptor reacts and binds with the analyte.

Claims

1. A biosensor, comprising:

an infrared light source generating a light;

an infrared absorber configured to have a resistance which varies corresponding to an intensity of the light absorbed thereby, the infrared absorber being a single, indivisible and unitary component, and the infrared absorber including at least two opposing end portions;

bioreceptors immobilized onto the infrared absorber and configured to selectively react and bind with an analyte; and

a measuring unit connected to both opposing end portions of the infrared absorber and configured to measure an induced voltage of the infrared absorber, the induced voltage being due to absorption of the light by the infrared absorber,

wherein the infrared absorber induces a first voltage when the light is applied thereto when the bioreceptors are unreacted and unbound to the analyte, and

wherein the infrared absorber induces a second voltage when the light is applied thereto when the bioreceptors are reacted and bound with the analyte.

2. The biosensor according to claim 1, further comprising:

a voltage amplifying part connected to the infrared absorber and configured for amplifying the induced voltage at the infrared absorber.

3. The biosensor according to claim 2, wherein the voltage amplifying part comprises a MOSFET, Bipolar transistor, or a combination including at least one of the foregoing.

4. The biosensor according to claim 2, wherein the infrared absorber and the voltage amplifying part are layered on a wafer.

5. The biosensor according to claim 2, further comprising an insulating layer formed on the voltage amplifying part;

and

a through-hole formed in the insulating layer for connecting the voltage amplifying part to the infrared absorber, the infrared absorber being formed on the insulating layer.

6. The biosensor according to claim 1, wherein the infrared absorber comprises Ti (titanium).

7. The biosensor according to claim 1, wherein the bioreceptor comprises enzyme, antibody, antigen, membrane, receptor, cell, tissue, DNA, or a combination including at least one of the foregoing.

8. A biosensor, comprising:

an infrared light source generating a light;

a substrate;

a plurality of infrared absorbers formed on the substrate, the plurality of infrared absorbers having a resistance which varies corresponding to an intensity of the light absorbed by each of the plurality of infrared absorbers, each of the plurality of infrared absorbers being a single, indivisible and unitary component;

a plurality of bioreceptors immobilized onto the infrared absorbers, the plurality of bioreceptors being of varying types configured for selectively reacting and binding with different analytes;

a plurality of voltage amplifying parts connected to the plurality of the infrared absorbers, for amplifying an induced voltage at each of the plurality of infrared absorbers; and

a measuring unit configured to measure an induced voltage of the plurality of infrared absorbers, the induced voltage being due to absorption of the light by the infrared absorber,

wherein the induced voltage at the infrared absorber varies depending on whether different kinds of bioreceptors react and bind with the analytes.

9. The biosensor according to claim 8, wherein the voltage amplifying part comprises a MOSFET, Bipolar transistor or a combination including at least one of the foregoing.

10. The biosensor according to claim 8, wherein the biosensor is layered on a wafer.

11. The biosensor according to claim 8, wherein the infrared absorber comprises Ti (titanium).

12. The biosensor according to claim 8, wherein the infrared absorber is shaped in a zigzag pattern to maximize the surface area covered by the infrared absorber and to thereby maximize infrared radiation absorption.

13. The biosensor according to claim 8, wherein the bioreceptor comprises enzyme, antibody, antigen, membrane, receptor, cell, tissue, DNA, or a combination including at least one of the foregoing.

14. The biosensor according to claim 8, further comprising a plurality of sensor units comprising the plurality of infrared absorbers and the plurality of voltage amplifying parts, the sensor units arranged in a grid pattern.

15. The biosensor according to claim 8, wherein the plurality of infrared absorbers each have a resistance varying in accordance with an amount of absorbed infrared radiation.

16. A biosensor system, comprising:

an infrared generator generating a light;

a biosensor including an infrared absorber which is a single, indivisible and unitary component, and which has a resistance which varies according to an amount of the light absorbed from the infrared generator, and bioreceptors immobilized onto the infrared absorber for selectively reacting and binding with an analyte, wherein, an induced voltage at the infrared absorber varies depending on whether the bioreceptor reacts and binds with the analyte; and

an output unit for displaying the variation in the induced voltage at the biosensor due to a variation in an amount of the light absorbed thereby.

17. The biosensor system according to claim 16, wherein the biosensor further comprises:

a voltage amplifying part connected to the infrared absorber, for amplifying the induced voltage at the infrared absorber.

18. The biosensor system according to claim 17, wherein the voltage amplifying part comprises a MOSFET, Bipolar transistor, or a combination including at least one of the foregoing.

19. The biosensor system according to claim 18, wherein the infrared absorber and the voltage amplifying part are layered on a wafer.

20. The biosensor system according to claim 16, wherein the infrared generator comprises an infrared lamp.

21. The biosensor system according to claim 16, wherein the infrared absorber comprises Ti (titanium).

22. The biosensor system according to claim 16, wherein the bioreceptor comprises enzyme, antibody, antigen, membrane, receptor, cell, tissue, DNA, or any combination including at least one of the foregoing.

23. The biosensor system according to claim 16, wherein the biosensor further comprises a support plate, the infrared absorbers formed on the support plate.