Biomaterial drug delivery and surface modification compositions
First Claim
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1. A blend comprising:
- a bioabsorbable terpolymer comprising from about 30 to about 50 weight percent of a polyoxyalkylene copolymer, from about 40 to about 50 weight percent epsilon-caprolactone, the balance of the copolymer comprising at least one other copolymerizable monomer selected from the group consisting of glycolide, lactide, p-dioxanone and trimethylene carbonate; and
a polymer comprising two or more monomers selected from the group consisting of lactide, glycolide, lactic-acid, lactones, glycolic acid;
carbonates, orthoesters, absorbable urethanes, absorbable nylons, polyethylene glycol-polypropylene glycol, polystyrene, n-vinyl pyrrolidine, n-vinyl pyridine, C1-C12 acrylate monomer, C1-C12 methacrylate monomer, hydroxyethyl methacrylate, hydroxypropyl methacrylate, acrylic acid, potassium sulfopropyl acrylate, potassium sulfopropyl methacrylate, and 2-methacryloyl phosphorocholine.
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Abstract
Compositions are provided which include a polymer made at least in part from a polyoxyalkylene copolymer, such as a poloxamer. The polymer may be combined with a second component to form a blend or emulsion. The resulting composition may be utilized to form medical devices, drug delivery devices, or coatings for other medical devices.
1134 Citations
30 Claims
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1. A blend comprising:
- a bioabsorbable terpolymer comprising from about 30 to about 50 weight percent of a polyoxyalkylene copolymer, from about 40 to about 50 weight percent epsilon-caprolactone, the balance of the copolymer comprising at least one other copolymerizable monomer selected from the group consisting of glycolide, lactide, p-dioxanone and trimethylene carbonate; and
a polymer comprising two or more monomers selected from the group consisting of lactide, glycolide, lactic-acid, lactones, glycolic acid;
carbonates, orthoesters, absorbable urethanes, absorbable nylons, polyethylene glycol-polypropylene glycol, polystyrene, n-vinyl pyrrolidine, n-vinyl pyridine, C1-C12 acrylate monomer, C1-C12 methacrylate monomer, hydroxyethyl methacrylate, hydroxypropyl methacrylate, acrylic acid, potassium sulfopropyl acrylate, potassium sulfopropyl methacrylate, and 2-methacryloyl phosphorocholine. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- a bioabsorbable terpolymer comprising from about 30 to about 50 weight percent of a polyoxyalkylene copolymer, from about 40 to about 50 weight percent epsilon-caprolactone, the balance of the copolymer comprising at least one other copolymerizable monomer selected from the group consisting of glycolide, lactide, p-dioxanone and trimethylene carbonate; and
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16. An emulsion comprising:
- a bioabsorbable terpolymer comprising about 30 to about 50 weight percent of a polyoxyalkylene copolymer, about 40 to about 50 weight percent epsilon-caprolactone, the balance of the copolymer comprising at least one other copolymerizable monomer selected from the group consisting of glycolide, lactide, p-dioxanone and trimethylene carbonate; and
a polymer derived from two or more monomers selected from the group consisting of lactide, glycolide, lactic acid, lactones, glycolic acid, carbonates, orthoesters, absorbable urethanes, absorbable nylons, polyethylene glycol-polypropylene glycol, polystyrene, n-vinyl pyrrolidine, n-vinyl pyridine, C1-C12 acrylate monomer, C1-C12 methacrylate monomer, hydroxyethyl methacrylate, hydroxypropyl methacrylate, acrylic acid, potassium sulfopropyl acrylate, potassium sulfopropyl methacrylate, and 2-methacryloyl phosphorocholine. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
- a bioabsorbable terpolymer comprising about 30 to about 50 weight percent of a polyoxyalkylene copolymer, about 40 to about 50 weight percent epsilon-caprolactone, the balance of the copolymer comprising at least one other copolymerizable monomer selected from the group consisting of glycolide, lactide, p-dioxanone and trimethylene carbonate; and
Specification