Standardization methods for correcting spectral differences across multiple spectroscopic instruments
First Claim
1. A method of determining a value of a property of a sample with a spectroscopic system, the method comprising:
- measuring, with a first spectroscopic system, spectra of a first set of at least three different reference targets, each having a known, unique reflectivity spectrum;
calibrating the first spectroscopic system based on the spectra of the first set of reference targets measured by the first spectroscopic system;
measuring, with the first spectroscopic system, a spectrum of a known reference specimen having a known value of a property;
generating a model for determining the property on the first spectroscopic system using the spectrum of the known reference specimen;
measuring, with a second spectroscopic system, spectra of a second set of at least three different reference targets, each having a known, unique reflectivity spectrum;
calibrating the second spectroscopic system based on the spectra of the second set of reference targets measured by the second spectroscopic system;
applying the model to the second spectroscopic system;
measuring a spectrum of a sample using the second spectroscopic system; and
determining a value of the property of the sample based on the spectrum of the sample measured by the second spectroscopic system using the model.
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Accused Products
Abstract
The invention relates to systems and methods for measuring properties of samples with standardized spectroscopic systems. The methods can include (i) measuring, with a first spectroscopic system, spectra of at least three different reference targets; (ii) calibrating the first spectroscopic system; (iii) measuring, with the first spectroscopic system, a spectrum of a known reference specimen having a known value of the property; (iv) generating a model for the measured property using the spectrum of the known reference specimen; (v) measuring, with a second spectroscopic system, the spectra of at least three different reference targets; (vi) calibrating the second spectroscopic system; (vii) applying the model to the second spectroscopic system; (viii) measuring a spectrum of the sample using the second spectroscopic system; and (ix) determining a value of the property using the model.
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Citations
43 Claims
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1. A method of determining a value of a property of a sample with a spectroscopic system, the method comprising:
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measuring, with a first spectroscopic system, spectra of a first set of at least three different reference targets, each having a known, unique reflectivity spectrum; calibrating the first spectroscopic system based on the spectra of the first set of reference targets measured by the first spectroscopic system; measuring, with the first spectroscopic system, a spectrum of a known reference specimen having a known value of a property; generating a model for determining the property on the first spectroscopic system using the spectrum of the known reference specimen; measuring, with a second spectroscopic system, spectra of a second set of at least three different reference targets, each having a known, unique reflectivity spectrum; calibrating the second spectroscopic system based on the spectra of the second set of reference targets measured by the second spectroscopic system; applying the model to the second spectroscopic system; measuring a spectrum of a sample using the second spectroscopic system; and determining a value of the property of the sample based on the spectrum of the sample measured by the second spectroscopic system using the model. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. A standardized spectroscopic system comprising:
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a light source; a spectrograph; a probe for receiving light from the light source that is reflected by a target; a processor configured to; (a) direct the light source to shine incident light on at least three different reference targets; (b) direct the spectrograph to obtain reflectivity spectra of the at least three different targets by measuring incident light that is reflected by the targets and received by the probe; (c) calculate calibration constants from the reflectivity spectra; and (d) prompt an operator to re-standardize the spectroscopic system after a selected time interval has elapsed since a previous standardization sequence; and a memory for storing the calibration constants. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A spectroscopic system, comprising:
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a light source; a spectrograph; a probe for receiving light from the light source that is reflected by a target; and a processor configured to; (a) receive information comprising a model for determining a value of a property using a different spectroscopic system, wherein the model is determined by; (i) measuring, with the different spectroscopic system, spectra of a first set of at least three different reference targets each having a known, unique reflectivity spectrum; (ii) calibrating the different spectroscopic system based on the spectra of the first set of reference targets; (iii) measuring, with the different spectroscopic system, a spectrum of a known reference specimen having a known value of the property; and (iv) generating the model for determining the value of the property using the different spectroscopic system from the spectrum of the known reference specimen; (b) measure spectra of a second set of at least three different reference targets each having a known, unique reflectivity spectrum; (c) calibrate the spectroscopic system based on the spectra of the second set of reference targets; (d) apply the model to the spectroscopic system; (e) measure a spectrum of a sample using the spectroscopic system; and (f) determine a value of the property in the sample based on the spectrum of the sample using the model. - View Dependent Claims (40, 41, 42, 43)
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Specification