Systems and methods for treating disorders of the central nervous system by modulation of brain networks
First Claim
1. A method of treating at least one symptom of a brain disorder with a neurostimulation device comprising a first stimulator and a second stimulator, the method comprising:
- operating the neurostimulation device to provide brain modulation of at least two regions of a brain network according to a treatment protocol;
wherein the modulation includes;
modulating a first brain region of the brain network using said first stimulator according to the treatment protocol configured with a first set of modulation parameters in order to provide treatment of the symptom;
modulating a second region of the brain network using said second stimulator according to the treatment protocol configured with a second set of modulation parameters in order to provide modulation to decrease a side-effect resulting at least in part from modulation in the first region; and
, wherein,said brain network has least one brain region associated with the symptom for which treatment is sought.
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Abstract
The present invention involves methods and systems for treatment of brain disorders using neuromodulation that is provided to modulate structures of brain networks. Treatment occurs using electrical, optical, magnetic, and/or chemical stimulation of one or more brain networks associated with a brain disorder. The methods involve using a brain modulation system (BMS) to increase, decrease, or otherwise modulate characteristics of the regions of the network, such as relative levels of electrical activity or neurotransmitter levels. Treatment can be initiated and adjusted based upon evaluation of functional neuroimaging data for the network and brain network modeling. Linking rules may guide in adjusting the treatment protocol used to provide neuromodulation of multiple regions of a brain network. Novel methods are described for addressing issues of compensation, adaptation, and unintentional modulation due to indirect stimulation that can arise due to connectivity between structures within brain networks.
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Citations
25 Claims
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1. A method of treating at least one symptom of a brain disorder with a neurostimulation device comprising a first stimulator and a second stimulator, the method comprising:
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operating the neurostimulation device to provide brain modulation of at least two regions of a brain network according to a treatment protocol;
wherein the modulation includes;modulating a first brain region of the brain network using said first stimulator according to the treatment protocol configured with a first set of modulation parameters in order to provide treatment of the symptom; modulating a second region of the brain network using said second stimulator according to the treatment protocol configured with a second set of modulation parameters in order to provide modulation to decrease a side-effect resulting at least in part from modulation in the first region; and
, wherein,said brain network has least one brain region associated with the symptom for which treatment is sought. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A neurostimulation system for treating at least one symptom of a brain disorder comprising:
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a stimulation subsystem configured for providing brain modulation of a brain network using least a first and a second stimulator according to a treatment protocol;
whereinthe treatment protocol comprises; modulating a first brain region of the brain network using a first set of modulation parameters that determines modulation provided by the first stimulator, said first set of modulation parameters designed to provide treatment of the symptom; modulating a second region of the brain network using a second set of modulation parameters that determines modulation provided by the second stimulator, said second set of modulation parameters designed to provide stimulation to decrease a side-effect, resulting at least in part from modulation in the first area; and
, wherein,said brain network has at least one brain region associated with the symptom for which treatment is sought. - View Dependent Claims (21, 22, 23, 24, 25)
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Specification