Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation

• US 7,955,613 B2
• Filed: 10/04/2004
• Issued: 06/07/2011
• Est. Priority Date: 10/02/2003
• Status: Expired due to Fees

• Current Assignee: Tikomed AB
• Original Assignee: Tikomed AB
• Inventors: Nilsson, Bo, Bruce, Lars, Korsgren, Olle, Bruce, Adam
• Primary Examiner(s): Weber; Jon P
• Assistant Examiner(s): GOUGH, TIFFANY MAUREEN
• Application Number:
  US10/574,114
• Publication Number:
  US 20060263405A1
• Time in Patent Office: 2,437 Days
• Field of Search: 424/423
• US Class Current: 424/423
• CPC Class Codes: A61F 2/022 Artificial gland structures using bioreactors hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Abstract

A bioartificial implant comprises a semipermeable barrier designed from one side to allow diffusion or prevent diffusion of predetermined substances/materials/molecules/cells/cell lines produced in the human body to the other opposite side of the barrier, and from said other opposite side to allow diffusion or prevent diffusion of predetermined substances which are the same as or different from the first mentioned substances/materials/molecules/cells/cell lines. The semipermeable barrier has a surface coating at least on said one side a bioactive metal, such as titanium, which surface coating is permeable to allow said diffusions. In a method for reducing the risk of formation/growth of connective tissue in connection with an implant which comprises a semipermeable barrier, the barrier is provided at least on one side with a permeable coating of bioactive metal. An example of the use of the implant is bioartificial pancreas.

Claims

1. A bioartificial implant, comprising:

a semipermeable barrier having a surface coating of a bioactive metal, the surface coating being permeable to not interfere with the semipermeability of the semipermeable barrier, wherein the semipermeable barrier is designed, to allow diffusion of body cell nutrients and oxygen from a donee'"'"'s body from a first side to a second opposite side of the semipermeable barrier where body organ/cells from a donor are positioned, and from the second opposite side and to the first side to allow diffusion of substances, produced by the donor'"'"'s body organs and cells.

2. An implant as claimed in claim 1, wherein said surface coating is a net of said bioactive metal.

3. An implant as claimed in claim 1, wherein said bioactive metal is selected from one of titanium, zirconium, tantalum or an alloy thereof.

4. An implant as claimed in claim 3, wherein said bioactive metal is titanium.

5. An implant as claimed in claim 1, wherein the metal is applied by an atomizing process.

6. An implant as claimed in claim 1, wherein the bioartificial implant is in the form of a container.

7. An implant as claimed in claim 1, wherein the semipermeable barrier has said surface coating on both sides.

8. An implant as claimed in claim 1, wherein the coating has a thickness greater than 5 nm.

9. An implant as claimed in claim 8, wherein the coating has a thickness of about 50-250 nm.

10. A bioartificial implant, comprising:

a semipermeable barrier having a surface coating of a bioactive metal, the surface coating being permeable to not interfere with the semipermeability of the semipermeable barrier; and

a sensor element enclosed by said semipermeable barrier, wherein the semipermeable barrier is designed, from a first side to allow diffusion of a substance to a second opposite side of the semipermeable barrier, the substance being detectable by the sensor element, and from the second opposite side to allow diffusion of the substance to the first side.

11. An implant as claimed in claim 10, wherein said substance is blood sugar and said sensor element is a blood-sugar detecting sensor element.

12. An insulin pump comprising:

a bioartificial implant as claimed in claim 11, and

an infusion set for delivering insulin based on a blood sugar level detected by said blood-sugar-detecting sensor element of said bioartificial implant, whereby said infusion set is provided with a semipermeable barrier having a surface coating of said bioactive metal, said surface coating being permeable to allow diffusion of insulin through said semipermeable barrier.