Methods for treating neovascularization and intravitreal implants
First Claim
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1. An intravitreal, bioerodible drug delivery system consisting essentially of about 50% by weight dexamethasone effective in preventing or reducing neovascularization in an eye prone to neovascularization, about 15% by weight hydroxypropyl methylcellulose, and about 35% by weight polylactic acid polyglycolic acid (PLGA) copolymer thereby forming an implant for placement into the vitreous of an eye prone to neovascularization.
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Abstract
Methods for reducing or preventing transplant rejection in the eye of an individual are described, comprising: a) performing an ocular transplant procedure; and b) implanting in the eye a bioerodible drug delivery system comprising an immunosuppressive agent and a bioerodible polymer.
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Citations
3 Claims
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1. An intravitreal, bioerodible drug delivery system consisting essentially of about 50% by weight dexamethasone effective in preventing or reducing neovascularization in an eye prone to neovascularization, about 15% by weight hydroxypropyl methylcellulose, and about 35% by weight polylactic acid polyglycolic acid (PLGA) copolymer thereby forming an implant for placement into the vitreous of an eye prone to neovascularization.
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2. An intravitreal, bioerodible drug delivery system consisting essentially of about 50% by weight dexamethasone effective in preventing or reducing neovascularization in an eye prone to neovascularization, about 15% by weight hydroxypropyl methylcellulose, and about 35% by weight polylactic acid polyglycolic acid (PLGA) copolymer.
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3. An intravitreal, bioerodible drug delivery system consisting essentially of about 50% by weight particles of dexamethasone, about 15% by weight hydroxypropyl methylcellulose, and about 35% by weight polylactic acid polyglycolic acid (PLGA) copolymer, wherein the system is effective in releasing the dexamethasone into the eye over a period of at least about 3 weeks, and wherein the intravitreal, bioerodible drug delivery system is a single pellet or a single extruded filament.
Specification