Integrated physiologic monitoring systems and methods
First Claim
1. A physiologic monitoring system including a physiologic monitoring application-specific integrated circuit, the integrated circuit comprising:
- amplification and filtering circuitry integrated on a semiconductor substrate, for amplifying and filtering a set of electrical signals received from a first set of physiologic sensors to generate a first set of filtered electrical signals, the amplification and filtering circuitry comprising analog filtering circuitry for filtering the set of electrical signals received from the first set of physiologic sensors, wherein the first set of physiologic sensors is a set of electrocardiogram sensors, and wherein the set of electrical signals received from the first set of physiologic sensors is a set of electrocardiogram electrical signals;
a real-time clock integrated on the semiconductor substrate, the real-time clock comprising a divider chain configured to frequency-divide a base timing signal to generate a real-time clock tick, wherein a frequency of signals generated by the real-time clock is within a frequency range of electrocardiogram electrical signals processed by the amplification and filtering circuitry; and
digital control logic integrated on the semiconductor substrate and connected to the real-time clock and the amplification and filtering circuitry;
the digital control logic being configured toreceive a first set of digital physiologic data derived from the first set of filtered electrical signals,receive a second set of digital physiologic data, wherein the second set of physiologic data includes physiologic data sampled with a different sampling rate than the first set of digital physiologic data,generate a time-stamped physiologic data packet from a real-time indicator, the first set of digital physiologic data and the second set of digital physiologic data, wherein the real-time indicator is generated according to the real-time clock tick; and
transmit the physiologic data packet for storage in a digital memory.
1 Assignment
0 Petitions
Accused Products
Abstract
In some embodiments, a wearable physiologic monitor comprises a mixed analog and digital application-specific integrated circuit (ASIC) including signal conditioning circuitry, an A/D converter, a real-time clock, and digital control logic. The signal conditioning circuitry includes analog amplification circuitry, analog (continuous-time or switched capacitor) filtering circuitry before the A/D converter, and in some embodiments digital (DSP) filtering circuitry after the A/D converter. The monitor includes sensors such as electrocardiogram (ECG) electrodes, accelerometers, and a temperature sensor, some of which may be integrated on the ASIC. The digital control logic receives digital physiologic data sampled at different rates, assembles the data into physiologic data packets, time-stamps at least some of the packets, and periodically stores the packets in a digital memory. The monitor may include a disposable patch including the ASIC, and a reusable, removable digital memory such as flash memory card. Applications include ambulatory monitoring and quantitative titration of care.
340 Citations
75 Claims
-
1. A physiologic monitoring system including a physiologic monitoring application-specific integrated circuit, the integrated circuit comprising:
-
amplification and filtering circuitry integrated on a semiconductor substrate, for amplifying and filtering a set of electrical signals received from a first set of physiologic sensors to generate a first set of filtered electrical signals, the amplification and filtering circuitry comprising analog filtering circuitry for filtering the set of electrical signals received from the first set of physiologic sensors, wherein the first set of physiologic sensors is a set of electrocardiogram sensors, and wherein the set of electrical signals received from the first set of physiologic sensors is a set of electrocardiogram electrical signals; a real-time clock integrated on the semiconductor substrate, the real-time clock comprising a divider chain configured to frequency-divide a base timing signal to generate a real-time clock tick, wherein a frequency of signals generated by the real-time clock is within a frequency range of electrocardiogram electrical signals processed by the amplification and filtering circuitry; and digital control logic integrated on the semiconductor substrate and connected to the real-time clock and the amplification and filtering circuitry; the digital control logic being configured to receive a first set of digital physiologic data derived from the first set of filtered electrical signals, receive a second set of digital physiologic data, wherein the second set of physiologic data includes physiologic data sampled with a different sampling rate than the first set of digital physiologic data, generate a time-stamped physiologic data packet from a real-time indicator, the first set of digital physiologic data and the second set of digital physiologic data, wherein the real-time indicator is generated according to the real-time clock tick; and transmit the physiologic data packet for storage in a digital memory. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
-
-
38. A wearable physiologic monitoring system comprising:
-
a battery; a plurality of electrocardiogram electrodes to be applied to a subject; a removable digital memory; and an application-specific integrated circuit connected to the removable digital memory, the battery, and the plurality of electrocardiogram electrodes, the integrated circuit comprising; amplification and filtering circuitry integrated on a semiconductor substrate and connected to the plurality of electrocardiogram electrodes, for amplifying and filtering a set of electrical signals received from the electrocardiogram electrodes to generate a set of filtered electrocardiogram data, the amplification and filtering circuitry comprising analog filtering circuitry for filtering the set of electrical signals received from the electrocardiogram electrodes; a real-time clock integrated on the semiconductor substrate, the real-time clock comprising a divider chain configured to frequency-divide a base timing signal to generate a real-time clock tick, wherein a frequency of signals generated by the real-time clock is within a frequency range of electrocardiogram electrical signals processed by the amplification and filtering circuitry; and digital control logic integrated on the semiconductor substrate and connected to the real-time clock and the amplification and filtering circuitry, the digital control logic being configured to assemble a time-stamped data packet including a set of digital electrocardiogram data derived from the filtered electrocardiogram data, the data packet being time-stamped according to a real-time indicator generated according to the real-time clock tick, and transmit the data packet for storage in the removable digital memory. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64)
-
-
65. A wearable physiologic monitoring system comprising:
-
a battery; a plurality of electrocardiogram electrodes to be applied to a subject; a digital memory; and an application-specific integrated circuit connected to the digital memory, the battery, and the plurality of electrocardiogram electrodes, the integrated circuit comprising; amplification and filtering circuitry integrated on a semiconductor substrate and connected to the plurality of electrocardiogram electrodes, for amplifying and filtering a set of electrical signals received from the electrocardiogram electrodes to generate a set of filtered electrocardiogram data, the amplification and filtering circuitry comprising analog filtering circuitry for filtering the set of electrical signals received from the electrocardiogram electrodes; a real-time clock integrated on the semiconductor substrate, the real-time clock comprising a divider chain configured to frequency-divide a base timing signal to generate a real-time clock tick, wherein a frequency of signals generated by the real-time clock is within a frequency range of electrocardiogram electrical signals processed by the amplification and filtering circuitry; and digital control logic integrated on the semiconductor substrate and connected to the real-time clock and the amplification and filtering circuitry, the digital control logic being configured to time-stamp a set of digital electrocardiogram data derived from the filtered electrocardiogram data according to a real-time indicator generated according to the real-time clock tick, and transmit a set of time-stamped digital electrocardiogram data for storage in the digital memory.
-
-
66. A physiologic monitoring system comprising:
-
electrocardiogram sensing means for sensing a set of electrocardiogram signals generated along a subject'"'"'s skin; wearable means connected to the electrocardiogram sending means and comprising; digital memory means; and an application-specific integrated circuit comprising signal conditioning means integrated on a semiconductor substrate, for amplifying and filtering a set of electrical signals received from the electrocardiogram sensing means; real-time means integrated on the semiconductor substrate, the real-time means comprising a divider chain configured to frequency-divide a base timing signal to generate a real-time clock tick, wherein a frequency of signals generated by the real-time means is within a frequency range of electrocardiogram electrical signals processed by the signal conditioning means; and digital control logic integrated on the semiconductor substrate and connected to the signal conditioning means, for time-stamping according to a set of real-time indicators a set of digital electrocardiogram data derived from the electrical signals, and transmitting a set of time-stamped digital electrocardiogram data to the digital memory means for storage, wherein the real-time indicators are generated according to the real-time clock tick.
-
-
67. A wearable physiologic monitoring system comprising:
-
a digital memory; a wearable patch comprising an integrated circuit connected to a plurality of electrocardiogram electrodes and the digital memory, the integrated circuit comprising; a temperature sensor integrated on a semiconductor substrate, for generating a set of subject temperature indicators; an accelerometer integrated on the semiconductor substrate, for generating a set of subject acceleration indicators; amplification and filtering circuitry integrated on the semiconductor substrate and connected to the plurality of electrocardiogram electrodes, for amplifying and filtering a set of electrical signals received from the electrocardiogram electrodes, the amplification and filtering circuitry comprising analog filtering circuitry for filtering the set of electrical signals received from the electrocardiogram electrodes; a real-time clock integrated on the semiconductor substrate, the real-time clock comprising a divider chain configured to frequency-divide a base timing signal to generate a real-time clock tick, wherein a frequency of signals generated by the real-time clock is within a frequency range of electrocardiogram electrical signals processed by the amplification and filtering circuitry; and digital control logic connected to the amplification and filtering circuitry, the temperature sensor and the accelerometer, the digital control logic being configured to assemble a physiologic data packet including digital electrocardiogram data derived from the set of electrical signals, temperature data derived from the set of subject temperature indicators, and acceleration data derived from the subject acceleration indicators, time-stamp the data packet according to a real-time indicator generated according to the real-time clock tick, and transmit the data packet to the digital memory for storage.
-
-
68. A physiologic monitoring method comprising:
-
sensing a first set of physiologic indicators generated by a subject using a first sensor set, wherein the first sensor set is a set of electrocardiogram sensors, and wherein sensing the first set of physiologic indicators comprises sensing a set of electrocardiogram electrical signals; and employing a mixed analog and digital application-specific integrated circuit comprising signal conditioning circuitry, a real-time clock and digital control logic integrated on a semiconductor substrate to amplify and filter the first set of physiologic indicators, employ a divider chain of the real-time clock to frequency-divide a base timing signal to generate a real-time clock tick, wherein a frequency of signals generated by the real-time clock is within a frequency range of electrocardiogram electrical signals processed by circuitry of the integrated circuit used to amplify and filter and first set of physiologic indicators, generate a first set of digital physiologic data from the first set of physiologic indicators at a first sampling rate, assemble the first set of digital physiologic data into a data packet, time-stamp the data packet according to a real-time indicator generated according to the real-time clock tick, and transmit the data packet for storage in a removable digital memory connected to the integrated circuit. - View Dependent Claims (69, 70, 71, 72, 73, 74, 75)
-
Specification