Analyte concentration detection devices and methods
First Claim
1. An arrangement constructed and arranged to detect the presence or concentration of an analyte present in bodily fluid, the arrangement comprising:
- a channel member configured to receive a sample of the bodily fluid from a conduit;
an assay pad in fluid communication with the channel member, the assay pad containing a reagent;
a plurality of detectors, each detector constructed and arranged to produce a signal indicative of a reaction between the analyte and the reagent; and
electronics constructed and arranged to monitor and interpret the signals produced by the plurality of detectors to provide the following outputs;
(i) an estimate of the volume of the sample received by the channel member based at least in part on the number of detectors that produce a signal indicating a reaction between the analyte and the reagent; and
(ii) information about the kinetics of the reaction between the analyte and the reagent based at least in part on the time between signals.
5 Assignments
0 Petitions
Accused Products
Abstract
Arrangements for the detection of the presence and/or concentration of an analyte in a sample of bodily fluid include diffuse transmission, diffuse reflection and edge or waveguide illumination arrangements. A vertical flow assay arrangement and/or technique is also disclosed, and includes a detection component that can be in the form of an array of optical detection elements. A number of assay pad constructions are described which may include at least one or more of the following components: a prefilter component, a reflective component, a membrane component, a reagent component, a mesh component, and a component to prevent lateral spreading.
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Citations
18 Claims
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1. An arrangement constructed and arranged to detect the presence or concentration of an analyte present in bodily fluid, the arrangement comprising:
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a channel member configured to receive a sample of the bodily fluid from a conduit; an assay pad in fluid communication with the channel member, the assay pad containing a reagent; a plurality of detectors, each detector constructed and arranged to produce a signal indicative of a reaction between the analyte and the reagent; and electronics constructed and arranged to monitor and interpret the signals produced by the plurality of detectors to provide the following outputs; (i) an estimate of the volume of the sample received by the channel member based at least in part on the number of detectors that produce a signal indicating a reaction between the analyte and the reagent; and (ii) information about the kinetics of the reaction between the analyte and the reagent based at least in part on the time between signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method useful in detecting the presence or concentration of an analyte present in bodily fluid, the method comprising:
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receiving a sample of the bodily fluid in a channel member; bringing the sample into contact with an assay pad, the assay pad containing a reagent; producing a plurality of signals from a plurality of detectors upon a reaction between the analyte and the reagent; and monitoring and interpreting the at least one signal to provide the following outputs; (i) an estimate of the volume of the sample received by the channel member based at least in part on the number of detectors that produce a signal indicating a reaction between the analyte and the reagent; and (ii) information about the kinetics of the reaction between the analyte and the reagent based at least in part on the time between signals. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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Specification