Amphiphilic or lipophilic polar functionalized fullerenes and their uses
First Claim
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1. A synthetically modified fullerene molecule having the formula
Zm—
- F—
Yn;
wherein F is fullerene of formula Cp, the fullerene having two opposing poles and an equatorial region;
Z and Y are positioned near respective opposite poles of Cp;
m=1-5 and Z is a hydrophilic chemical moiety;
n=1-5 and Y is a lipophilic chemical moiety;
p=60-120 and p is an even number.
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Abstract
Described herein are synthetically modified fullerene molecules, wherein the fullerene is preferably ellipsoid in shape with an equatorial band and two opposing poles, comprising an adduct at one or both poles, at least one adduct being a hydrophobic chemical moiety capable of anchoring the fullerene on or in a lipid membrane.
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Citations
17 Claims
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1. A synthetically modified fullerene molecule having the formula
Zm—- F—
Yn;wherein F is fullerene of formula Cp, the fullerene having two opposing poles and an equatorial region; Z and Y are positioned near respective opposite poles of Cp; m=1-5 and Z is a hydrophilic chemical moiety; n=1-5 and Y is a lipophilic chemical moiety; p=60-120 and p is an even number. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- F—
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13. A synthetic fullerene molecule having the formula Z(C70)Y;
- wherein Y is a lipophilic moiety covalently connected to C70, optionally through a linking group, near a pole thereof, and wherein Z is a hydrophilic moiety covalently connected to C70, optionally through a linking group, at or near a pole opposite to said Y; and
, wherein said lipophilic moiety Y is capable of anchoring the synthetic fullerene molecule to a lipid membrane. - View Dependent Claims (14, 15, 16, 17)
- wherein Y is a lipophilic moiety covalently connected to C70, optionally through a linking group, near a pole thereof, and wherein Z is a hydrophilic moiety covalently connected to C70, optionally through a linking group, at or near a pole opposite to said Y; and
Specification