Blood pump with expandable cannula

• US 8,535,211 B2
• Filed: 07/01/2010
• Issued: 09/17/2013
• Est. Priority Date: 07/01/2009
• Status: Active Grant

• Current Assignee: TC1 LLC (Abbott Laboratories Incorporated), Penn State Research Foundation, Thoratec LLC
• Original Assignee: Penn State Research Foundation, Thoratec LLC
• Inventors: Campbell, Robert L., Walsh, Justin M., Metrey, Daniel, Kunz, Robert F., Mallison, Thomas M., Boone, Edward, Myer, Eric, McBride, Mark W., Powell, Kevin J., Walters, Daniel A.
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US12/829,359
• Publication Number:
  US 20110004046A1
• Time in Patent Office: 1,174 Days
• Field of Search: 607/46, 607 59- 60, 600/16
• US Class Current: 600/16
• CPC Class Codes: A61M 60/13 by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
• CPC Class Codes: A61M 60/139 inside the aorta, e.g. intra-aortic balloon pumps
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/237 the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
• CPC Class Codes: A61M 60/414 transmitted by a rotating cable, e.g. for blood pumps mounted on a catheter
• CPC Class Codes: A61M 60/422 the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
• CPC Class Codes: A61M 60/808 specially adapted for deformable impellers, e.g. expandable impellers
• CPC Class Codes: A61M 60/857 Implantable blood tubes
• CPC Class Codes: A61M 60/894 Passive valves, i.e. valves actuated by the blood

Abstract

A blood pump includes an impeller having a plurality of foldable blades and a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller can reside in the expandable portion of the cannula. The cannula has a collapsed condition for percutaneous delivery to a desired location within the body, and an expanded condition in which the impeller can rotate to pump blood. A flexible drive shaft can extend through the cannula for rotationally driving the impeller within the patient'"'"'s body.

Claims

1. An apparatus for inducing motion of a fluid relative to the apparatus, comprising:

an elongated expandable cannula having an inlet end, an outlet end and a diameter expandable to a diameter greater than a delivery diameter, the expandable cannula comprising;

a generally tubular reinforcing matrix; and

a polymer at least partially disposed over an exterior of the reinforcing matrix;

an impeller positioned in the elongated expandable cannula; and

a retainer sheath configured to be withdrawn from the expandable cannula to permit the expandable cannula to expand and to be advanceable over the expandable cannula to compress the expandable cannula;

wherein the expandable cannula is configured to be collapsed by the retainer sheath without requiring a funnel or other distally enlarged structure.

2. The apparatus of claim 1, the impeller having a deployed configuration and a stored configuration, the impeller comprising:

a hub; and

a blade supported by the hub, the blade having a proximal end attached to the hub and a distal end, the blade in the deployed configuration of the impeller extending away from the hub, and the blade in the stored configuration of the impeller being compressed so as to move the distal end of the blade towards the hub.

3. An apparatus for inducing motion of a fluid relative to the apparatus, the apparatus comprising:

an elongated cannula having an expandable portion having an inlet end, an outlet end and a diameter expandable to a diameter greater than a delivery diameter, the expandable portion comprising;

a generally tubular reinforcing matrix comprising;

a plurality of circumferential rings each having an undulating pattern including a plurality of apexes pointing proximally and defining a plurality of recesses distally;

a plurality of connectors connecting one of the apexes pointing proximally in one of the rings to an adjacent one of the rings; and

an impeller positioned in the elongated cannula.

4. The apparatus of claim 3, further comprising a connector that extends between a first end connected to an apex of a first circumferential ring and a second end connected to an apex of a second circumferential ring.

5. The apparatus of claim 3, wherein the impeller has a deployed configuration and a stored configuration.

6. The apparatus of claim 5, wherein the impeller comprises a hub and a blade supported by the hub, the blade having a proximal end attached to the hub and a distal end, the blade in the deployed configuration of the impeller extending away from the hub, and the blade in the stored configuration of the impeller being compressed so as to move the distal end of the blade towards the hub.

7. The apparatus of claim 6, wherein the impeller comprises a plurality of blades.

8. The apparatus of claim 3, further comprising a connector that extends between a first end connected to an apex of a first circumferential ring and a second end connected to a side of a second circumferential ring.

9. The apparatus of claim 3, wherein the elongated cannula comprises a proximal portion and a distal portion, the proximal portion including a conduit having a fixed diameter and the distal portion including the expandable portion.

10. The apparatus of claim 3, further comprising a valve positioned in the impeller and having a first condition for occluding flow of a first fluid through the impeller from a first end to a second end of the impeller, and a second condition for occluding flow of a second fluid through the impeller from the second end to the first end.

11. The apparatus of claim 3, further comprising:

a vane assembly positioned in the expandable portion distally of the impeller and having a deployed configuration and a stored configuration, the vane assembly comprising;

a vane hub; and

a plurality of vanes supported by the vane hub, each of the vanes having a proximal end attached to the vane hub and a distal end,

the vanes in the deployed configuration of the vane assembly extending away from the vane hub, and the in the stored configuration of the vane assembly being compressed so as to move the distal ends of the vanes towards the vane hub;

wherein the vane assembly is connected to the impeller so that the vane assembly moves with the impeller in a longitudinal direction of the elongated cannula and so that the vane assembly does not rotate with the impeller.

12. The apparatus of claim 3, further comprising a hub axially offset from the impeller, the hub having a plurality of members extending radially therefrom.

13. The apparatus of claim 12, wherein the radially extending members comprise a plurality of vanes.

14. The apparatus of claim 13, wherein the hub and vanes are disposed distal of the impeller.

15. The apparatus of claim 12, wherein the radially extending members foldable against the hub from which they extend.

16. The apparatus of claim 3, the apparatus further comprising:

a sheath having a generally non-expanding distal portion,

wherein the expandable portion of the cannula comprises a proximal end, a distal end, a duct extending between the proximal and distal ends, and

wherein the distal portion of the sheath is configured to move relative to the proximal end of the expandable portion.

17. The apparatus of claim 16, wherein, when relative motion is provided between the distal portion of the sheath and the proximal end of the expandable portion, the distal portion of the retainer sheath applies a force having a radial component to a proximal end of one of the connectors to induce radial collapse of a distal region of the duct to facilitate collapse of the expandable portion into the sheath.

18. The apparatus of claim 17, further comprising a polymeric rib structure disposed axially along the duct.

19. The apparatus of claim 17, wherein the apparatus comprises a spacing device disposed adjacent to the impeller for maintaining an operating separation between the impeller and the duct.

20. The apparatus of claim 3, further comprising a valve positioned in a lumen accessible through the impeller and having a first condition for occluding flow of a fluid and a second configuration for permitting a guidewire to pass therethrough.

21. The apparatus of claim 12, wherein the radially extending members are configured to contact an inner wall of the expandable portion to control a gap between the impeller and the wall of the expandable portion.

22. The apparatus of claim 3, further comprising a plurality of vanes disposed downstream of the impeller.

23. The apparatus of claim 22, wherein the vanes are disposed proximally of the impeller.

24. The apparatus of claim 3, further comprising members disposed downstream of the impeller having a foil type cross-section.

25. An apparatus for inducing motion of a fluid relative to the apparatus, comprising:

an elongated cannula having an expandable portion having an inlet end, an outlet end and a diameter expandable to a diameter greater than a delivery diameter, the expandable portion comprising;

a generally tubular reinforcing matrix;

a layer of a first polymer at least partially coating an exterior of the reinforcing matrix, the reinforcing matrix including a plurality of circumferential rings each having an undulating pattern including a plurality of apexes pointing toward the outlet end and defining a plurality of recesses pointing toward the inlet end;

the reinforcing matrix including members coupled at distal ends with a corresponding apexes, the members having proximal ends disposed proximal of the corresponding apex; and

at least one region of a second polymer different from the first polymer that overlies the first polymer layer and extends between one of the apexes pointing toward the outlet end in one of the rings and at least one other ring; and

an impeller positioned in the elongated cannula.

26. The apparatus of claim 25, wherein the impeller has a deployed configuration and a stored configuration, the impeller comprising a hub and a blade supported by the hub, the blade having a proximal end attached to the hub and a distal end, the blade in the deployed configuration of the impeller extending away from the hub, and the blade in the stored configuration of the impeller being compressed so as to move the distal end of the blade towards the hub.