Methods for modifying vascular vessel walls

• US 8,641,776 B2
• Filed: 03/15/2011
• Issued: 02/04/2014
• Est. Priority Date: 12/07/2004
• Status: Active Grant

• Current Assignee: Cook Biotech Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Biotech Incorporated (Cook Group Incorporated), Cook Medical Technologies, LLC (Cook Group Incorporated)
• Inventors: Case, Brian C., Hiles, Michael C., Flagle, Jacob A., Obermiller, F. Joseph, Patel, Umesh H.
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): Mathew, Seema
• Application Number:
  US13/048,458
• Publication Number:
  US 20110171181A1
• Time in Patent Office: 1,057 Days
• Field of Search: 424/93.7, 424/643, 623/1.41, 623/1.45, 623/1.48, 623/1.35, 623/1.42, 623/1.44, 623/23.72
• US Class Current: 623/23.72
• CPC Class Codes: A61B 17/12 for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord specially adapted for vas deferens or fallopian tubes A61F6/20; materials for ligaturing blood vessels A61L17/00
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2002/077 having means to fill the space between stent-graft and aneurysm wall, e.g. a sleeve
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.

Claims

1. A method for treating a wall of a vascular vessel, the method comprising injecting into the wall an injectable composition comprising an extracellular matrix hydrolysate and extracellular matrix particles, so as to modify the function, strength, or integrity of the vessel wall.

2. The method of claim 1 wherein the composition also comprises viable cells.

3. The method of claim 2 wherein the cells are endothelial cells, fibroblastic cells, smooth muscle cells, cardiac muscle cells, multipotent progenitor cells, stem cells, or pericytes.

4. The method of claim 3 wherein the cells are endothelial cells.

5. The method of claim 3 wherein the cells are cardiac muscle cells.

6. The method of claim 3 wherein the cells are multipotent progenitor cells or stem cells.

7. The method of claim 1 wherein the extracellular matrix particles contain at least one retained native growth factor from a source tissue for the particles.

8. The method of claim 7 wherein the growth factor is FGF-2.

9. The method of claim 1 wherein the vascular vessel is a vein or an artery.

10. The method of claim 1, wherein said method is effective to increase the elasticity of the vessel wall.

11. The method of claim 1, further wherein the injectable composition is intra-lumenally delivered to the vascular wall.

12. A method for treating a wall of a vascular vessel, the method comprising injecting into the wall a flowable composition comprising a remodelable extracellular matrix material retaining at least one native growth factor from a source tissue for the extracellular matrix material, so as to modify the function, strength, or integrity of the vessel wall.

13. The method of claim 12 wherein the composition also comprises viable cells.

14. The method of claim 13 wherein the cells are endothelial cells, fibroblastic cells, smooth muscle cells, cardiac muscle cells, multipotent progenitor cells, stem cells, or pericytes.

15. The method of claim 14 wherein the cells are endothelial cells.

16. The method of claim 14 wherein the cells are cardiac muscle cells.

17. The method of claim 14 wherein the cells are multipotent progenitor cells or stem cells.

24. The method of claim 12, wherein said method is effective to increase the elasticity of the vessel wall.

26. The method of claim 12, further wherein the flowable composition is intra-lumenally delivered to the vascular wall.

18. A method for treating a wall of a vascular vessel, the method comprising injecting into the wall a flowable composition comprising an angiogenic, remodelable extracellular matrix material, so as to modify the function, strength, or integrity of the vessel wall.

19. The method of claim 18 wherein the composition also comprises viable cells.

20. The method of claim 19 wherein the cells are endothelial cells, fibroblastic cells, smooth muscle cells, cardiac muscle cells, multipotent progenitor cells, stem cells, or pericytes.

21. The method of claim 20 wherein the cells are endothelial cells.

22. The method of claim 20 wherein the cells are cardiac muscle cells.

23. The method of claim 20 wherein the cells are multipotent progenitor cells or stem cells.

25. The method of claim 18, wherein said method is effective to increase the elasticity of the vessel wall.

27. The method of claim 18, further wherein the flowable composition is intra-lumenally delivered to the vascular wall.