Titration dosing regimen for controlled release tramadol
First Claim
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1. A dosage regimen for administering tramadol to a patient for the treatment of pain comprising administering:
- about 100 mg of tramadol in a controlled release dosage form once-a-day on days 1 through 7;
then about 200 mg of tramadol in a controlled release dosage form once-a-day on days 8 through 14;
then about 300 mg of tramadol in a controlled release dosage form once-a-day on day 15 and optionally thereafter.
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Abstract
A titration dosing regimen for the administration of controlled release tramadol analgesic to patients. The titration dosing regimen provides a significant reduction in the occurrence of adverse effects from the introduction of controlled released tramadol dosing, thus increasing patient compliance and medication tolerability.
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Citations
20 Claims
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1. A dosage regimen for administering tramadol to a patient for the treatment of pain comprising administering:
- about 100 mg of tramadol in a controlled release dosage form once-a-day on days 1 through 7;
then about 200 mg of tramadol in a controlled release dosage form once-a-day on days 8 through 14;
then about 300 mg of tramadol in a controlled release dosage form once-a-day on day 15 and optionally thereafter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- about 100 mg of tramadol in a controlled release dosage form once-a-day on days 1 through 7;
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9. A dosage regimen for administering tramadol to a patient for the treatment of pain comprising administering:
- about 175 mg to about 225 mg of tramadol in a controlled release dosage form once-a-day for about 4 to about 10 days;
then about 275 mg to about 325 mg of tramadol in a controlled release dosage form once-a-day for at least 1 day and optionally thereafter. - View Dependent Claims (10, 11, 12, 13)
- about 175 mg to about 225 mg of tramadol in a controlled release dosage form once-a-day for about 4 to about 10 days;
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14. A dosage regimen for administering tramadol to a patient for the treatment of pain comprising administering:
- about 200 mg of tramadol in a controlled release dosage form once-a-day for days 1 through 7;
then about 300 mg of tramadol in a controlled release dosage form once-a-day for at least 1 day and optionally thereafter. - View Dependent Claims (15, 16, 17, 18)
- about 200 mg of tramadol in a controlled release dosage form once-a-day for days 1 through 7;
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19. A kit for the administration of a dosage regimen of tramadol comprising:
- instructions to administer the following amounts of tramadol in controlled release oral dosage forms according to the following dosage regimen;
100 mg of tramadol once-a-day on days 1 through 7;
200 mg of tramadol once-a-day on about days 8 through 14; and
300 mg of tramadol once-a-day on about days 15 through 21, and optionally thereafter; and
a sufficient quantity of controlled release oral dosage forms of tramadol to administer tramadol according to the dosage regimen.
- instructions to administer the following amounts of tramadol in controlled release oral dosage forms according to the following dosage regimen;
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20. A kit for the administration of a dosage regimen of tramadol comprising:
- instructions to administer the following amounts of tramadol in controlled release oral dosage forms according to the following dosage regimen;
200 mg of tramadol once-a-day on days 1 through 7; and
300 mg of tramadol once-a-day on about days 8 through 14, and optionally thereafter; and
a sufficient quantity of controlled release oral dosage forms of tramadol to administer tramadol according to the dosage regimen.
- instructions to administer the following amounts of tramadol in controlled release oral dosage forms according to the following dosage regimen;
Specification