Rehydratable polysaccharide particles and sponge
First Claim
1. A composition comprising free-flowing rehydratable sterilized particles comprising dehydrothermally crosslinked polysaccharide comprising chitosan in sealed packaging, the particles containing a sufficiently low amount of collagen so as not to pose a potential risk of transmission of or infection with bovine spongiform encephalopathy (BSE) or variant Creutzfeldt-Jakob disease (vCJD) and the particles providing a polysaccharide gel when rehydrated.
3 Assignments
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Accused Products
Abstract
Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.
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Citations
12 Claims
- 1. A composition comprising free-flowing rehydratable sterilized particles comprising dehydrothermally crosslinked polysaccharide comprising chitosan in sealed packaging, the particles containing a sufficiently low amount of collagen so as not to pose a potential risk of transmission of or infection with bovine spongiform encephalopathy (BSE) or variant Creutzfeldt-Jakob disease (vCJD) and the particles providing a polysaccharide gel when rehydrated.
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11. A method for making a sterilized polysaccharide gel-forming composition, which method comprises:
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a) providing a substantially collagen-free polysaccharide solution comprising chitosan; b) drying the solution to form a powder; c) dehydrothermally crosslinking the powder to form free-flowing particles that will provide a polysaccharide gel when rehydrated; d) sealing the dehydrothermally crosslinked powder in a packaging material; and e) sterilizing the powder.
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12. A method for treating mucosal tissue or structures in or near the ears, nose or throat and openings, recesses, passageways or joints in the limbs or spinal column, which method comprises applying thereto a gel comprising rehydrated sterilized substantially collagen-free dehydrothermally crosslinked chitosan.
Specification