Analyte sensor
First Claim
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1. A system for measuring an analyte in a sample of a host and for infusion into the host comprising:
- an analyte sensor configured to measure an analyte concentration in a biological sample of a circulatory system of a host, wherein the analyte sensor is located in at least one of a fluid coupler lumen or a lumen of a vascular access device;
a fluid control device configured to both intermittently draw the biological sample from the host to the analyte sensor and to intermittently expose the sensor to a reference solution via the fluid coupler lumen or the lumen of a vascular access device; and
a computer system, wherein the computer system comprises;
an input module configured to receive sensor analyte data and reference analyte data, wherein the sensor data comprises one or more sensor analyte values measured in the biological sample from the circulatory system of the host and wherein the reference data comprises one or more reference analyte values measured in the reference solution introduced into the circulatory system of the host; and
a processor module configured to intermittently calculate a sensitivity of the analyte sensor before the sensor is stabilized and during a break-in period of the sensor based at least in part on the reference analyte data and to evaluate a change in sensitivity by evaluating a plurality of time-spaced sensitivity calculations over a predetermined time period.
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Abstract
Systems and methods of use for continuous analyte measurement of a host'"'"'s vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host'"'"'s circulatory system.
889 Citations
27 Claims
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1. A system for measuring an analyte in a sample of a host and for infusion into the host comprising:
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an analyte sensor configured to measure an analyte concentration in a biological sample of a circulatory system of a host, wherein the analyte sensor is located in at least one of a fluid coupler lumen or a lumen of a vascular access device; a fluid control device configured to both intermittently draw the biological sample from the host to the analyte sensor and to intermittently expose the sensor to a reference solution via the fluid coupler lumen or the lumen of a vascular access device; and a computer system, wherein the computer system comprises; an input module configured to receive sensor analyte data and reference analyte data, wherein the sensor data comprises one or more sensor analyte values measured in the biological sample from the circulatory system of the host and wherein the reference data comprises one or more reference analyte values measured in the reference solution introduced into the circulatory system of the host; and a processor module configured to intermittently calculate a sensitivity of the analyte sensor before the sensor is stabilized and during a break-in period of the sensor based at least in part on the reference analyte data and to evaluate a change in sensitivity by evaluating a plurality of time-spaced sensitivity calculations over a predetermined time period. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 27)
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26. A system for measuring an analyte in a sample of a host and for infusion into the host comprising:
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an analyte sensor configured to measure an analyte concentration in a biological sample of a circulatory system of a host; a fluid control device configured to both intermittently draw the biological sample from the host to the analyte sensor and to intermittently expose the sensor to a reference solution via the fluid coupler lumen or the lumen of a vascular access device; and a computer system, wherein the computer system comprises; an input module configured to receive sensor analyte data and reference analyte data, wherein the sensor data comprises one or more sensor analyte values measured in a biological sample from the vasculature of the host and wherein the reference data comprises one or more reference analyte values measured in the reference solution introduced into the circulatory system of the host; and a processor module configured to intermittently calculate a sensitivity of the analyte sensor based at least in part on the reference analyte data and to evaluate a change in sensitivity by evaluating a plurality of time-spaced sensitivity calculations over a predetermined time period; wherein the processor module is configured to intermittently calculate a sensitivity of the analyte sensor before the sensor is stabilized and during a break-in period of the sensor based on a signal obtained when the analyte sensor is exposed to the biological sample within the vasculature system and a signal obtained when the analyte sensor is exposed to the reference solution; and wherein the analyte sensor data comprises a first signal comprising an analyte component and a baseline component.
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Specification