Artificial tissue systems and uses thereof
First Claim
1. An implant system, comprising:
- (a) a sensor having an outer surface including an analyte permeable coating,(b) a biological matrix comprising a cell culture derived basement membrane exterior to the sensor and in contact with the analyte permeable coating on the outer surface of the sensor and with biological tissue, and(c) a plurality of cells supported by the biological matrix, the plurality of cells comprising cells expressing vascular endothelial growth factor and extending sensor functionality by promoting a biological interaction between the sensor and the biological tissue.
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Accused Products
Abstract
An implant system and a method for controlling the natural and artificial microenvironments surrounding an implanted device using an artificial tissue system (ATS) and includes methods of diagnostic and testing related thereto. The ATS, among other things, induce better integration, function, and extended lifespan of the devices at the site of implantation. The ATS includes cells, such as naturally occurring, engineered, and/or artificial cells; matrices such as natural, engineered, artificial and/or hybrid matrices; tissue response modifiers (TRM); and/or cell response modifiers (CRM). The specific composition of the ATS is based on the nature of the tissue in which ATS-device combination is implanted and the nature of the implant device, as well as the required function and lifespan of the implanted device. Additionally, the ATS, as well as ATSdevice combinations can be utilized in vitro to aid in the design of improved ATS, devices and ATS-device combinations for in \>ivo uses.
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Citations
23 Claims
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1. An implant system, comprising:
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(a) a sensor having an outer surface including an analyte permeable coating, (b) a biological matrix comprising a cell culture derived basement membrane exterior to the sensor and in contact with the analyte permeable coating on the outer surface of the sensor and with biological tissue, and (c) a plurality of cells supported by the biological matrix, the plurality of cells comprising cells expressing vascular endothelial growth factor and extending sensor functionality by promoting a biological interaction between the sensor and the biological tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 12, 14, 15, 21, 22)
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8. An implant system comprising:
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(a) an implantable sensor having an outer surface including an analyte permeable coating, (b) a biological matrix comprising cell culture derived basement membrane, the biological matrix being positioned exterior to the sensor and in contact with the analyte permeable coating on the outer surface of the sensor, and (c) a plurality of cells supported by said biological matrix, the plurality of cells comprising cells expressing vascular endothelial growth factor and being configured to extend sensor functionality when the sensor and matrix are implanted in biological tissue by promoting neovascularization of the biological tissue. - View Dependent Claims (13, 16, 17, 23)
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9. An implant system in biological contact with biological tissue comprising:
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(a) a cellular component, said cellular component includes at least one cellular community comprising cells expressing vascular endothelial growth factor; (b) a biological matrix material comprising a cell culture derived basement membrane in contact with the biological tissue, said biological matrix material being associated with a portion of the cellular community; and (c) a sensor having an outer surface including an analyte permeable coating in contact with the biological matrix material, at least one of the biological matrix material and the cellular community extending sensor functionality by promoting neovascularization of the biological tissue, wherein the biological matrix is exterior to the sensor. - View Dependent Claims (10, 11, 18, 19, 20)
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Specification